Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium.
United European Gastroenterol J. 2024 Mar;12(2):240-251. doi: 10.1002/ueg2.12508. Epub 2023 Dec 16.
In recent decades, the prevalence of type 2 diabetes has been steadily increasing, presenting a significant global public health challenge. These epidemiological trends can be attributed to significant lifestyle changes in modern societies, characterized by sedentary behavior and the consumption of hypercaloric, highly processed foods, along with the aging of the human population. As a result, it has become crucial for both public healthcare systems and healthcare providers to prioritize the management of diabetes and identify its systemic consequences. Emerging research has shed light on the links and risks between diabetes and liver events. This comprehensive review aims to explore the complex interplay between type 2 diabetes mellitus and liver-related outcomes, especially hepatocellular carcinoma and cirrhosis, offering insights into effective methods for detecting liver risk in individuals with diabetes. Additionally, the review will assess the various treatments that could hold the potential for positive outcomes in managing both diabetes and metabolic dysfunction-associated steatotic liver disease and liver fibrosis.
近几十年来,2 型糖尿病的患病率稳步上升,这是一个重大的全球公共卫生挑战。这些流行病学趋势可以归因于现代社会生活方式的重大变化,其特征是久坐不动的行为和高卡路里、高度加工食品的消费,以及人口老龄化。因此,优先管理糖尿病并识别其系统后果对于公共医疗保健系统和医疗保健提供者来说至关重要。新兴研究揭示了糖尿病与肝脏事件之间的联系和风险。本综述旨在探讨 2 型糖尿病与肝相关结局(特别是肝细胞癌和肝硬化)之间的复杂相互作用,探讨在糖尿病个体中检测肝脏风险的有效方法。此外,本综述还将评估各种治疗方法,这些方法可能对管理糖尿病和代谢功能障碍相关脂肪性肝病和肝纤维化有积极作用。