Elmakki Erwa Eltayib
Department of Internal Medicine, Faculty of Medicine, Jazan University, Jazan, SAU.
Cureus. 2024 Aug 3;16(8):e66074. doi: 10.7759/cureus.66074. eCollection 2024 Aug.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common complication in patients with type 2 diabetes mellitus (T2DM), potentially progressing to more severe conditions such as metabolic dysfunction-associated steatohepatitis (MASH), liver cirrhosis, and hepatocellular carcinoma. This case study presents a 55-year-old man with long-standing T2DM who was found to have deranged liver function tests, elevated serum iron, and hyperferritinemia during a routine follow-up visit. The patient's clinical presentation, laboratory findings, and imaging results led to a diagnosis of MASH, complicated by dysregulated iron metabolism. This case highlights the importance of vigilant monitoring of liver function and iron studies in T2DM patients. Furthermore, it illustrates the challenges in managing the complex interplay between metabolic syndrome, liver dysfunction, and cardiovascular risk.
代谢功能障碍相关脂肪性肝病（MASLD）是2型糖尿病（T2DM）患者常见的并发症，可能进展为更严重的疾病，如代谢功能障碍相关脂肪性肝炎（MASH）、肝硬化和肝细胞癌。本病例研究介绍了一名55岁患有长期T2DM的男性，在一次常规随访中发现其肝功能检查结果异常、血清铁升高和铁蛋白血症。患者的临床表现、实验室检查结果和影像学结果导致诊断为MASH，并伴有铁代谢失调。该病例强调了对T2DM患者肝功能和铁代谢研究进行密切监测的重要性。此外，它还说明了在管理代谢综合征、肝功能障碍和心血管风险之间复杂相互作用方面所面临的挑战。
