Health Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Environmental Health Engineering, Faculty of Health, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Sci Rep. 2023 Dec 16;13(1):22402. doi: 10.1038/s41598-023-49290-z.
Following the advent of the coronavirus pandemic, tocilizumab has emerged as a potentially efficacious therapeutic intervention. The utilization of O-Heterogeneous photocatalytic process (O-HPCP) as a hybrid advanced oxidation technique has been employed for the degradation of pollutants. The present study employed a solvothermal technique for the synthesis of the BiOI-MOF composite. The utilization of FTIR, FESEM, EDAX, XRD, UV-vis, BET, TEM, and XPS analysis was employed to confirm the exceptional quality of the catalyst. the study employed an experimental design, subsequently followed by the analysis of collected data in order to forecast the most favorable conditions. The purpose of this study was to investigate the impact of several factors, including reaction time (30-60 min), catalyst dose (0.25-0.5 mg/L), pH levels (4-8), ozone concentration (20-40 mMol/L), and tocilizumab concentration (10-20 mg/L), on the performance of O-HPCP. The best model was discovered by evaluating the F-value and P-value coefficients, which were found to be 0.0001 and 347.93, respectively. In the given experimental conditions, which include a catalyst dose of 0.46 mg/L, a reaction time of 59 min, a pH of 7.0, and an ozone concentration of 32 mMol/L, the removal efficiencies were found to be 92% for tocilizumab, 79.8% for COD, and 59% for TOC. The obtained R value of 0.98 suggests a strong correlation between the observed data and the predicted values, indicating that the reaction rate followed first-order kinetics. The coefficient of synergy for the degradation of tocilizumab was shown to be 1.22. The catalyst exhibited satisfactory outcomes, but with a marginal reduction in efficacy of approximately 3%. The sulfate ion (SO) exhibited no influence on process efficiency, whereas the nitrate ion (NO) exerted the most significant impact among the anions. The progress of the process was impeded by organic scavengers, with methanol exhibiting the most pronounced influence and sodium azide exerting the least significant impact. The efficacy of pure BiOI and NH-MIL125 (Ti) was diminished when employed in their pure form state. The energy consumption per unit of degradation, denoted as EEO, was determined to be 161.8 KWh/m-order.
在冠状病毒大流行之后，托珠单抗已成为一种潜在有效的治疗干预手段。O-Heterogeneous 光催化工艺 (O-HPCP) 作为一种混合高级氧化技术已被用于污染物的降解。本研究采用溶剂热技术合成了 BiOI-MOF 复合材料。利用 FTIR、FESEM、EDAX、XRD、UV-vis、BET、TEM 和 XPS 分析来确认催化剂的优异质量。研究采用实验设计，随后对收集到的数据进行分析，以预测最有利的条件。本研究的目的是研究包括反应时间 (30-60 分钟)、催化剂剂量 (0.25-0.5 毫克/升)、pH 值 (4-8)、臭氧浓度 (20-40 毫摩尔/升) 和托珠单抗浓度 (10-20 毫克/升) 在内的多个因素对 O-HPCP 性能的影响。通过评估 F 值和 P 值系数，发现最佳模型，它们分别为 0.0001 和 347.93。在给定的实验条件下，包括催化剂剂量为 0.46 毫克/升、反应时间为 59 分钟、pH 值为 7.0 和臭氧浓度为 32 毫摩尔/升，托珠单抗的去除效率为 92%，COD 为 79.8%，TOC 为 59%。获得的 R 值为 0.98，表明观察数据与预测值之间存在很强的相关性，表明反应速率遵循一级动力学。托珠单抗降解的协同系数为 1.22。催化剂表现出令人满意的结果，但效果略有下降，约为 3%。硫酸根离子 (SO) 对过程效率没有影响，而硝酸根离子 (NO) 是所有阴离子中影响最大的。甲醇是有机清除剂中影响最大的，叠氮化钠是影响最小的，它们对过程的进展有阻碍作用。纯 BiOI 和 NH-MIL125(Ti) 的效率在纯态下降低。单位降解能耗，记为 EEO，为 161.8 KWh/m-阶。
