Gelin J, Rehfeld J F, Jansson R, Svanvik J
Surgery. 1987 Feb;101(2):201-4.
Cholecystectomy will not always relieve the abdominal symptoms of the patient with gallstones. The functional effects of gallbladder removal in a patient with a patent cystic duct are not known in detail. Studies of the function of the gallbladder and pancreas have suggested feedback mechanisms for the release of cholecystokinin (CCK). A disturbed regulation of CCK release after cholecystectomy might induce pancreaticobiliary and gastrointestinal dysfunctions. In our study the concentrations of CCK in plasma were measured in 17 patients with gallstones. The measurements were taken with gallbladders opacified at cholecystography and with patent cystic ducts at the operation, in the fasting state, and during stimulation before and 17 weeks after the cholecystectomy. The CCK assay used measures sulfated CCK-8, CCK-22, and CCK-33 with equimolar potency but neither nonsulfated CCK nor any gastrins. Emtobil (containing peanut oil and sorbitol) was used for peroral stimulation of the CCK release. The basal concentration of CCK was 4 pmol/L and rose five times during a "test meal." No significant differences were seen in fasting or stimulated concentrations of plasma CCK before and after the cholecystectomy. Thus cholecystectomy in gallstone patients with functioning gallbladders does not seem to influence the regulation of CCK release.
胆囊切除术并不总能缓解胆结石患者的腹部症状。胆囊切除对胆囊管通畅患者的功能影响尚不清楚。对胆囊和胰腺功能的研究表明存在胆囊收缩素（CCK）释放的反馈机制。胆囊切除术后CCK释放调节紊乱可能会诱发胰胆和胃肠功能障碍。在我们的研究中，对17例胆结石患者的血浆CCK浓度进行了测量。测量在胆囊造影时胆囊显影且手术时胆囊管通畅的患者中进行，分别在空腹状态下、胆囊切除术前及术后17周刺激期间进行。所使用的CCK检测方法可等量测定硫酸化CCK - 8、CCK - 22和CCK - 33，但不能测定非硫酸化CCK和任何胃泌素。使用恩托必利（含花生油和山梨醇）经口刺激CCK释放。CCK的基础浓度为4 pmol/L，在“试餐”期间升高了五倍。胆囊切除术前和术后空腹或刺激状态下的血浆CCK浓度未见显著差异。因此，对于胆囊功能正常的胆结石患者，胆囊切除术似乎不影响CCK释放的调节。
