Prasad Trupti Nagendra, Arjunan Durairaj, Pal Rimesh, Bhadada Sanjay Kumar
Department of Endocrinology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Indian J Orthop. 2023 Dec 12;57(Suppl 1):209-217. doi: 10.1007/s43465-023-01049-4. eCollection 2023 Dec.
Bone fragility is an emerging complication of diabetes. People with diabetes are at a significantly higher risk of fractures compared to the general population. Bone fragility occurs in diabetes as a result of complex and poorly understood mechanisms occurring at the cellular level contributed by vascular, inflammatory and mechanical derangements. Bone mineral density (BMD) as assessed by DEXA is low in type 1 diabetes. Type 2 diabetes has a high risk of fracture despite a normal to raised BMD. DEXA thus underestimates the fracture risk in diabetes. Data are scare regarding the efficacy of the available therapies in this low bone turnover state.
骨脆性是糖尿病新出现的一种并发症。与普通人群相比，糖尿病患者发生骨折的风险显著更高。糖尿病中骨脆性的发生是由血管、炎症和机械紊乱在细胞水平上引发的复杂且尚未完全了解的机制导致的。通过双能X线吸收法（DEXA）评估的骨矿物质密度（BMD）在1型糖尿病中较低。2型糖尿病尽管BMD正常或升高，但骨折风险较高。因此，DEXA低估了糖尿病患者的骨折风险。关于现有疗法在这种低骨转换状态下的疗效的数据很少。
