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One-Pot Solvothermal Synthetic Route of a Zinc Oxide Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite: An Advanced Material with a Novel Anticancer Theranostic Approach.

作者信息

Kanth Kadiyala Nalinee, Mandal Badal Kumar, Kumar Reddy L Vinod, Sen Dwaipayan, Tammina Sai Kumar, Barnes Crispin H W, Alvarez Manuel Ñique, De Los Santos Valladares Luis, Kotakadi Venkata Subbaiah, Gaddam Susmila Aparna

机构信息

Trace Elements Speciation Research Laboratory, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology (VIT), Vellore 632014, India.

Cellular and Molecular Therapeutics Laboratory, Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology (VIT), Vellore 632014, India.

出版信息

ACS Omega. 2023 Nov 28;8(49):46763-46776. doi: 10.1021/acsomega.3c06082. eCollection 2023 Dec 12.

DOI:10.1021/acsomega.3c06082
PMID:38107885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10720013/
Abstract

This study focuses on a one-pot solvothermal synthetic route for the preparation of uniformly decorated zinc oxide nanoparticles on the surface of reduced graphene oxide (rGO/ZnO-NC) by using leaf aqueous extract as an eco-friendly reducing agent. After characterizing the samples by different physical and chemical techniques, the anticancer activity of the synthesized rGO/ZnO-NC was examined on two human cancerous cell lines (HCT116 and A549) and one normal cell line (hMSCs). The MTT assays revealed that rGO/ZnO-NC exhibited dose-dependent cytotoxicity at a maximum concentration range of 10 ppm and the viability of the cells was drastically decreased to 95-96%. Measurement of reactive oxygen species (ROS) generation and Annexin V-FTIC staining assay revealed that rGO/ZnO-NC induced apoptosis in HCT116 and A549 cell lines. Thus, this study shows that the green-synthesized rGO/ZnO-NC has great potential in developing an efficacious novel therapeutic agent for cancers.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/a36f28cffcce/ao3c06082_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/645026e392ad/ao3c06082_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/6c46650b4df4/ao3c06082_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/ee2302c31114/ao3c06082_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/67457c39ef37/ao3c06082_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/d52065623637/ao3c06082_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/895cbe4d1872/ao3c06082_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/0a6b4a3eef8a/ao3c06082_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/27c08e70aaee/ao3c06082_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/a36f28cffcce/ao3c06082_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/645026e392ad/ao3c06082_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/6c46650b4df4/ao3c06082_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/ee2302c31114/ao3c06082_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/67457c39ef37/ao3c06082_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/d52065623637/ao3c06082_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/895cbe4d1872/ao3c06082_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/0a6b4a3eef8a/ao3c06082_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/27c08e70aaee/ao3c06082_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ba/10720013/a36f28cffcce/ao3c06082_0009.jpg

相似文献

[1]
One-Pot Solvothermal Synthetic Route of a Zinc Oxide Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite: An Advanced Material with a Novel Anticancer Theranostic Approach.

ACS Omega. 2023-11-28

[2]
Efficient One-Pot Solvothermal Synthesis and Characterization of Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposites: Evaluation of Their Enhanced Anticancer Activity toward Human Cancer Cell Lines.

ACS Omega. 2023-1-3

[3]
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[4]
Facile green synthesis of ZnO-RGO nanocomposites with enhanced anticancer efficacy.

Methods. 2022-3

[5]
Enhanced Anticancer Performance of Eco-Friendly-Prepared Mo-ZnO/RGO Nanocomposites: Role of Oxidative Stress and Apoptosis.

ACS Omega. 2022-2-15

[6]
Biosynthesis, Characterization, and Augmented Anticancer Activity of ZrO Doped ZnO/rGO Nanocomposite.

J Funct Biomater. 2023-1-9

[7]
Hierarchical zinc oxide/reduced graphene oxide composite: Preparation route, mechanism study and lithium ion storage.

J Colloid Interface Sci. 2019-7-15

[8]
Reduced graphene oxide-silver nanoparticle nanocomposite: a potential anticancer nanotherapy.

Int J Nanomedicine. 2015-10-5

[9]
Apoptosis inducing ability of silver decorated highly reduced graphene oxide nanocomposites in A549 lung cancer.

Int J Nanomedicine. 2016-3-7

[10]
Ecofriendly synthesized reduced graphene oxide embellished marsh marigold-like zinc oxide nanocomposite based on ultrasonication technique for the sensitive detection of environmental pollutant hydroquinone.

Ultrason Sonochem. 2019-6-18

本文引用的文献

[1]
Efficient One-Pot Solvothermal Synthesis and Characterization of Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposites: Evaluation of Their Enhanced Anticancer Activity toward Human Cancer Cell Lines.

ACS Omega. 2023-1-3

[2]
Drug-eluting PCL/graphene oxide nanocomposite scaffolds for enhanced osteogenic differentiation of mesenchymal stem cells.

Mater Sci Eng C Mater Biol Appl. 2020-10

[3]
Reduced Graphene Oxide Incorporated GelMA Hydrogel Promotes Angiogenesis For Wound Healing Applications.

Int J Nanomedicine. 2019-12-5

[4]
3D graphene-based gel photocatalysts for environmental pollutants degradation.

Environ Pollut. 2019-7-9

[5]
DADLE enhances viability and anti-inflammatory effect of human MSCs subjected to 'serum free' apoptotic condition in part via the DOR/PI3K/AKT pathway.

Life Sci. 2017-12-15

[6]
Graphene-Based Materials for Stem Cell Applications.

Materials (Basel). 2015-12-11

[7]
Preparation and Morphology Studies of Nano Zinc Oxide Obtained Using Native and Modified Chitosans.

Materials (Basel). 2013-9-18

[8]
ROS in Cancer: The Burning Question.

Trends Mol Med. 2017-5

[9]
The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles.

Int J Mol Sci. 2017-1-10

[10]
Apoptosis inducing ability of silver decorated highly reduced graphene oxide nanocomposites in A549 lung cancer.

Int J Nanomedicine. 2016-3-7

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