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核心技术专利：CN118964589B侵权必究
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Efficient One-Pot Solvothermal Synthesis and Characterization of Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposites: Evaluation of Their Enhanced Anticancer Activity toward Human Cancer Cell Lines.

作者信息

Kanth Kadiyala Nalinee, Mandal Badal Kumar, Kumar Reddy L Vinod, Barnes Crispin H W, De Los Santos Valladares Luis, Sen Dwaipayan

机构信息

Trace Elements Speciation Research Laboratory, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology (VIT), Vellore 632014, India.

Cellular and Molecular Therapeutics Laboratory, Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology (VIT), Vellore 632014, India.

出版信息

ACS Omega. 2023 Jan 3;8(2):2406-2420. doi: 10.1021/acsomega.2c06822. eCollection 2023 Jan 17.

DOI:10.1021/acsomega.2c06822
PMID:36687032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9850483/
Abstract

This study mainly deals with an effective one-pot solvothermal synthetic pathway for the preparation of uniformly dispersed zirconium oxide nanoparticles on the flattened rough surface of reduced graphene oxide (ZrO/rGO NCs) using the aqueous leaf extract of . After obtaining detailed information on the preparation and characterization, the anticancer activity of the synthesized ZrO/rGO nanocrystals (NCs) was evaluated on two human cancer cell lines (A549 and HCT116) along with one normal human cell line (hMSC). The 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide assays revealed that ZrO/rGO NCs exhibited a dose-dependent cytotoxicity pattern. The cell viability (%) drastically decreases up to 96-98% after exposure to an optimal concentration of 10 ppm nanocomposites. Analysis of both the reactive oxygen species generation and the Annexin V-FTIC staining assays reveal that ZrO/rGO NCs have the ability to induce apoptosis in A549 and HCT116 cell lines. Thus, the green synthesis of ZrO/rGO NCs shows potential in developing efficient therapeutic agents for cancer therapy.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/9bfda44c0d12/ao2c06822_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/3a7dbf6e0c54/ao2c06822_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/617bbe555eac/ao2c06822_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/feb0d505bc16/ao2c06822_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/a1eeb228bbf1/ao2c06822_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/7cb998d7c7cf/ao2c06822_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/69dc55cbc40c/ao2c06822_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/6644e8277d31/ao2c06822_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/9bfda44c0d12/ao2c06822_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/3a7dbf6e0c54/ao2c06822_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/617bbe555eac/ao2c06822_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/feb0d505bc16/ao2c06822_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/a1eeb228bbf1/ao2c06822_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/7cb998d7c7cf/ao2c06822_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/69dc55cbc40c/ao2c06822_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/6644e8277d31/ao2c06822_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4483/9850483/9bfda44c0d12/ao2c06822_0009.jpg

相似文献

[1]
Efficient One-Pot Solvothermal Synthesis and Characterization of Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposites: Evaluation of Their Enhanced Anticancer Activity toward Human Cancer Cell Lines.

ACS Omega. 2023-1-3

[2]
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[4]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
NiO@rGO nanohybrids triggered cytotoxicity via oxidative stress, cell cycle arrest, and apoptosis pathways.

Sci Rep. 2025-7-1

[2]
One-Pot Solvothermal Synthetic Route of a Zinc Oxide Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite: An Advanced Material with a Novel Anticancer Theranostic Approach.

ACS Omega. 2023-11-28

[3]
Biomedical Applications of Zirconia-Based Nanomaterials: Challenges and Future Perspectives.

Molecules. 2023-7-15

本文引用的文献

[1]
New approaches and procedures for cancer treatment: Current perspectives.

SAGE Open Med. 2021-8-12

[2]
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

CA Cancer J Clin. 2018-9-12

[3]
Graphene oxide regulates cox2 in human embryonic kidney 293T cells via epigenetic mechanisms: dynamic chromosomal interactions.

Nanotoxicology. 2018-1-16

[4]
DADLE enhances viability and anti-inflammatory effect of human MSCs subjected to 'serum free' apoptotic condition in part via the DOR/PI3K/AKT pathway.

Life Sci. 2017-12-15

[5]
Nano-zirconia - Evaluation of its antioxidant and anticancer activity.

J Photochem Photobiol B. 2017-4-8

[6]
ROS in Cancer: The Burning Question.

Trends Mol Med. 2017-5

[7]
Photocatalytic activity against azo dye and cytotoxicity on MCF-7 cell lines of zirconium oxide nanoparticle mediated using leaves of Lagerstroemia speciosa.

J Photochem Photobiol B. 2017-3-3

[8]
Phytoremediation of dyes using Lagerstroemia speciosa mediated silver nanoparticles and its biofilm activity against clinical strains Pseudomonas aeruginosa.

J Photochem Photobiol B. 2017-3

[9]
The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles.

Int J Mol Sci. 2017-1-10

[10]
Graphene in Regenerative Medicine: Focus on Stem Cells and Neuronal Differentiation.

Trends Biotechnol. 2016-2-12

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