Chen Xiaohong, Yang Liqun, Wu Yanfang, Wang Lina, Li Huafeng
Department of Pediatric Internal Medicine, Haining Central Hospital, Jiaxing 314400, China.
Department of Nursing, Tongxiang Traditional Chinese Medicine Hospital, Jiaxing 314500, China.
ACS Omega. 2023 Nov 28;8(49):46362-46375. doi: 10.1021/acsomega.3c06944. eCollection 2023 Dec 12.
Photothermal therapy is a promising approach to cancer treatment. The energy generated by the photothermal effect can effectively inhibit the growth of cancer cells without harming normal tissues, while the right amount of heat can also promote cell proliferation and accelerate tissue regeneration. Various nanomaterials have recently been used as photothermal agents (PTAs). The photothermal composite scaffolds can be obtained by introducing PTAs into bone tissue engineering (BTE) scaffolds, which produces a photothermal effect that can be used to ablate bone cancer with subsequent further use of the scaffold as a support to repair the bone defects created by ablation of osteosarcoma. Osteosarcoma is the most common among primary bone malignancies. However, a review of the efficacy of different types of photothermal composite scaffolds in osteosarcoma is lacking. This article first introduces the common PTAs, BTE materials, and preparation methods and then systematically summarizes the development of photothermal composite scaffolds. It would provide a useful reference for the combination of tumor therapy and tissue engineering in bone tumor-related diseases and complex diseases. It will also be valuable for advancing the clinical applications of photothermal composite scaffolds.
光热疗法是一种很有前景的癌症治疗方法。光热效应产生的能量可以有效抑制癌细胞生长而不损害正常组织，适量的热量还能促进细胞增殖并加速组织再生。近年来，各种纳米材料被用作光热剂（PTA）。通过将光热剂引入骨组织工程（BTE）支架中可获得光热复合支架，其产生的光热效应可用于消融骨癌，随后该支架还可进一步用作支撑物来修复骨肉瘤消融所造成的骨缺损。骨肉瘤是原发性骨恶性肿瘤中最常见的一种。然而，目前缺乏对不同类型光热复合支架治疗骨肉瘤疗效的综述。本文首先介绍了常见的光热剂、骨组织工程材料及制备方法，然后系统总结了光热复合支架的发展情况。这将为骨肿瘤相关疾病及复杂疾病的肿瘤治疗与组织工程相结合提供有益参考。对于推进光热复合支架的临床应用也具有重要价值。
