1Medical Faculty in Skopje, Ss. Cyril and Methodius University in Skopje, RN Macedonia.
2Department of General Surgery, Prof. Dr. Cemil Taşçıoğlu Şehir Hastanesi, Istanbul, Turkey.
Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2023 Dec 18;44(3):73-78. doi: 10.2478/prilozi-2023-0049. Print 2023 Dec 1.
: Lymphovascular Invasion (LVI) and Perineural Invasion (PNI) represent undesirable but still realistic pathological features of rectal cancer, associated with poor prognosis and worse survival. The aim of this study is to assess the incidence of LVI and PNI in patients treated for rectal cancer and the impact of LVI and PNI on patient survival. : This retrospective single center observational study, conducted in the period of 2016-2019, includes patients with rectal cancer treated with/without long-course neoadjuvant chemoradiotherapy (nCRT). Data collection encompassed demographics, tumor characteristics, type of surgery (abdominal perineal rectal resection - APR and low anterior rectal resection - LAR), and LVI/PNI presence. Survival during follow-up was estimated and compared for patients with/without LVI and PNI involvement. : A total number of 234 patients (77 females and 157 males) with mean age of 61.3 enrolled in the study. Neoadjuvant CRT was conducted in 170 patients. APR procedure was performed in 67 of them and LAR in 167. LVI presence was noted in 55 (24.4%) and PNI in 77 (34.2%) patients. Mean survival during follow-up was 42.07 months. The use of nCRT influenced on survival (p < 0.033). Patients treated with LAR had better survival outcomes (p = 0.001). Presence of LVI and PNI was associated with a worse prognosis (p < 0.001). : PNI was more frequent than the LVI in this study. Patients with nCRT conduction had better overall survival. LVI and PNI presence was associated with poor prognosis in terms of overall survival in patients with rectal cancer.
: 淋巴管浸润（LVI）和神经周围浸润（PNI）是直肠癌不理想但仍现实的病理特征，与预后不良和生存率下降有关。本研究旨在评估接受直肠癌治疗患者的 LVI 和 PNI 发生率，以及 LVI 和 PNI 对患者生存的影响。 : 这项回顾性单中心观察性研究于 2016 年至 2019 年进行，纳入接受/未接受长程新辅助放化疗（nCRT）治疗的直肠癌患者。数据收集包括人口统计学、肿瘤特征、手术类型（腹会阴直肠切除术 - APR 和低位前切除术 - LAR）以及 LVI/PNI 存在情况。在随访期间估计并比较了有/无 LVI 和 PNI 参与的患者的生存情况。 : 共有 234 名（77 名女性和 157 名男性）平均年龄为 61.3 岁的患者入组本研究。170 名患者接受 nCRT。其中 67 例行 APR 手术，167 例行 LAR 手术。55 名（24.4%）患者存在 LVI，77 名（34.2%）患者存在 PNI。在随访期间，平均生存时间为 42.07 个月。nCRT 的使用影响生存（p < 0.033）。接受 LAR 治疗的患者生存结果更好（p = 0.001）。存在 LVI 和 PNI 与预后不良相关（p < 0.001）。 : 在本研究中，PNI 比 LVI 更为常见。接受 nCRT 治疗的患者总体生存率更好。LVI 和 PNI 存在与直肠癌患者总体生存率的不良预后相关。
