基于血液的免疫系统标志物与偏头痛状态之间无关联：一项基于人群的队列研究。

No association between blood-based markers of immune system and migraine status: a population-based cohort study.

机构信息

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Department of Internal Medicine, Maasstad Hospital, Rotterdam, the Netherlands.

出版信息

BMC Neurol. 2023 Dec 18;23(1):445. doi: 10.1186/s12883-023-03496-w.

DOI:10.1186/s12883-023-03496-w

PMID:38110925

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10726636/

Abstract

BACKGROUND

Although some evidence implicates the immune system in migraine attacks, its role during attack-free periods remains largely unexplored. Therefore, we assessed the association between the immune system and migraine status.

METHODS

From the population-based Rotterdam Study, we included 6593 participants who underwent blood sampling and migraine assessments. In the blood samples, we measured white blood-cell-based immune markers. As a marker for the innate immune system, granulocyte and platelet counts were determined, whereas lymphocyte counts were used as a marker for the adaptive immune system. Migraine was assessed using a validated questionnaire based on ICHD-2 criteria. We investigated associations between blood-cell counts and migraine using logistic regression models adjusting for age, sex and other variables.

RESULTS

Mean age of participants was 65.6 ± 11.2 years and 56.7% were female. The lifetime prevalence of migraine was 15.1% (995/6593). We found no statistically significant associations between granulocyte (odds ratio [OR] per standard deviation increase 1.01 95% Confidence Interval [CI]: 0.93-1.09), platelet (OR 1.01 CI: 0.94-1.09) or lymphocyte counts (OR 1.01 CI: 0.93-1.08) and migraine status.

CONCLUSIONS

Our results do not support an association between white blood-cell-based immunity markers and migraine status.

摘要

背景

尽管有一些证据表明免疫系统与偏头痛发作有关，但在无发作期间其作用仍在很大程度上未被探索。因此，我们评估了免疫系统与偏头痛状态之间的关联。

方法

我们从基于人群的鹿特丹研究中纳入了 6593 名参与者，这些参与者接受了血液采样和偏头痛评估。在血液样本中，我们测量了基于白细胞的免疫标志物。粒细胞和血小板计数被确定为先天免疫系统的标志物，而淋巴细胞计数被用作适应性免疫系统的标志物。偏头痛是使用基于 ICHD-2 标准的经过验证的问卷进行评估的。我们使用逻辑回归模型调整了年龄、性别和其他变量来研究血细胞计数与偏头痛之间的关联。

结果

参与者的平均年龄为 65.6±11.2 岁，其中 56.7%为女性。偏头痛的终身患病率为 15.1%（995/6593）。我们没有发现粒细胞（每标准偏差增加的优势比 [OR] 1.01，95%置信区间 [CI]：0.93-1.09）、血小板（OR 1.01 CI：0.94-1.09）或淋巴细胞计数（OR 1.01 CI：0.93-1.08）与偏头痛状态之间存在统计学显著关联。