Gut Barrier and Disease Laboratory, Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia.
Department of Medicine, Western Health, The University of Melbourne, Melbourne, Victoria, Australia.
Obes Rev. 2024 Mar;25(3):e13673. doi: 10.1111/obr.13673. Epub 2023 Dec 18.
Systemic inflammation is a key contributor to the onset and progression of several obesity-associated diseases and is thought to predominantly arise from the hyperplasia and hypertrophy of white adipose tissue. However, a growing body of works suggests that early changes in the gastrointestinal (GI) barrier may contribute to both local, within the GI lining, and systemic inflammation in obesity. Intestinal barrier dysfunction is well-characterized in inflammatory GI disorders such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and is known to contribute to systemic inflammation. Thus, drawing parallels between GI disorders, where intestinal permeability and systemic inflammation are prominent features, and obesity-induced GI manifestations may provide insights into the potential role of the intestinal barrier in systemic inflammation in obesity. This review summarizes the current literature surrounding intestinal barrier dysfunction in obesity and explores the potential role of intestinal hyperpermeability and intestinal barrier dysfunction in the development of systemic inflammation and GI dysfunction in obesity.
系统性炎症是多种肥胖相关疾病发病和进展的一个关键因素，其主要被认为源自白色脂肪组织的增生和肥大。然而，越来越多的研究表明，胃肠道（GI）屏障的早期变化可能导致肥胖症中局部（在 GI 衬里内）和全身性炎症。肠道屏障功能障碍在炎症性 GI 疾病（如炎症性肠病（IBD）和肠易激综合征（IBS））中得到了很好的描述，并且已知会导致全身性炎症。因此，将 GI 疾病（其中肠道通透性和全身性炎症是突出特征）与肥胖引起的 GI 表现进行类比，可能有助于了解肠道屏障在肥胖症全身性炎症中的潜在作用。本综述总结了肥胖症中肠道屏障功能障碍的现有文献，并探讨了肠道高通透性和肠道屏障功能障碍在肥胖症全身性炎症和 GI 功能障碍发展中的潜在作用。
