Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, LON-207, Boston, MA, 02114, USA.
Curr Obes Rep. 2019 Jun;8(2):165-174. doi: 10.1007/s13679-019-00332-6.
Obesity is a state of chronic inflammation. This review aims to summarize recent data supporting the role of the intestinal mucosal barrier and the microbiome in causing adipose tissue inflammation as well as metabolic factors that can affect the intestinal barrier.
Obesity and its metabolic consequences, such as diabetes mellitus, are associated with disruption of the intestinal barrier function. Intestinal microbiota and diet play a key role in the maintenance of a healthy intestinal epithelium. Intestinal barrier dysfunction can lead to heightened inflammation, which in turn can further damage the intestinal barrier through the disruption of tight junction proteins. Intestinal barrier breakdown is associated with adipose tissue inflammation in different disease states, such as obesity, diabetes mellitus, HIV, and inflammatory bowel disease. Future therapeutic strategies to ameliorate intestinal barrier function may help reduce inflammation in obesity and other chronic conditions of increased intestinal permeability.
肥胖是一种慢性炎症状态。本综述旨在总结近期数据，以支持肠道黏膜屏障和微生物组在引起脂肪组织炎症以及可能影响肠道屏障的代谢因素中的作用。
肥胖及其代谢后果，如糖尿病，与肠道屏障功能障碍有关。肠道微生物群和饮食在维持健康的肠道上皮中起着关键作用。肠道屏障功能障碍可导致炎症加剧，而炎症反过来又可通过破坏紧密连接蛋白进一步损害肠道屏障。在不同疾病状态下，如肥胖、糖尿病、HIV 和炎症性肠病，肠道屏障破坏与脂肪组织炎症有关。改善肠道屏障功能的未来治疗策略可能有助于减轻肥胖和其他肠道通透性增加的慢性疾病中的炎症。
