Okura Shohei, Deguchi Yasuhiko, Cho Tetsuji, Kageyama Yuki, Inoue Koki
Neuropsychiatry, Osaka Metropolitan University Graduate School of Medicine, Osaka, JPN.
Psychiatry, Shigisan Hospital Heartland Shigisan, Nara, JPN.
Cureus. 2023 Nov 18;15(11):e49005. doi: 10.7759/cureus.49005. eCollection 2023 Nov.
Antipsychotics are frequently used to treat psychiatric disorders and have been associated with weight gain. Mental disorders are likely to reduce patients' quality of life. Unhealthy lifestyles such as reduced physical activity, sleep disturbances, and irregular diets can lead to weight gain. Herein, we report two cases of schizophrenia and bipolar disorder who had a 10-kg gain in weight in six months with the administration of lurasidone and valproic acid. Lurasidone has fewer side effects, such as weight gain and somnolence. However, concomitant use of sedating antipsychotics or mood stabilizers in the acute phase and multiple doses increase the risk of weight gain. Additionally, various factors, including psychiatric symptoms and lifestyle changes, are believed to contribute to weight gain, and a comprehensive approach should be followed.
抗精神病药物常用于治疗精神疾病，且与体重增加有关。精神疾病可能会降低患者的生活质量。诸如身体活动减少、睡眠障碍和饮食不规律等不健康的生活方式会导致体重增加。在此，我们报告两例精神分裂症和双相情感障碍患者，他们在使用鲁拉西酮和丙戊酸治疗六个月后体重增加了10公斤。鲁拉西酮的副作用较少，如体重增加和嗜睡。然而，在急性期同时使用镇静性抗精神病药物或心境稳定剂以及多次给药会增加体重增加的风险。此外，包括精神症状和生活方式改变在内的各种因素被认为会导致体重增加，因此应采取综合方法。
