Dong Ming-Xing, Wang Xi-Xia, Jiao Fu-Yong, Zhang Wei-Hua
Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712000, China/Xianyang Children's Hospital, Xianyang,Shaanxi 712000, China (Zhang W-H, Email: xiangyuelanda2006@126. com).
Zhongguo Dang Dai Er Ke Za Zhi. 2023 Dec 15;25(12):1234-1238. doi: 10.7499/j.issn.1008-8830.2308073.
Kawasaki disease (KD) is a systemic inflammatory vascular disorder that predominantly affects children and is the leading cause of acquired heart disease in children. Although the etiology of this disease remains unclear, genome-wide association and genome-wide linkage studies have shown that some susceptible genes and chromosomal regions are associated with the development and progression of KD. With the advancement of high-throughput DNA sequencing techniques, more and more genomic information related to KD is being discovered. Understanding the genes involved in the pathogenesis of KD may provide novel insights into the diagnosis and treatment of KD. By analyzing related articles and summarizing related research advances, this article mainly discusses the T cell activation-enhancing genes that have been confirmed to be closely associated with the development and progression of KD and reveals their association with the pathogenesis of KD and coronary artery lesions.
川崎病（KD）是一种主要影响儿童的全身性炎症性血管疾病，是儿童后天性心脏病的主要原因。尽管该疾病的病因尚不清楚，但全基因组关联研究和全基因组连锁研究表明，一些易感基因和染色体区域与KD的发生和发展有关。随着高通量DNA测序技术的进步，越来越多与KD相关的基因组信息被发现。了解参与KD发病机制的基因可能为KD的诊断和治疗提供新的见解。通过分析相关文章并总结相关研究进展，本文主要讨论已被证实与KD的发生和发展密切相关的T细胞激活增强基因，并揭示它们与KD发病机制和冠状动脉病变的关联。
