[辅助生殖技术对双胎出生体重不一致性的影响]
[Impact of assisted reproductive technology on birth weight discordance in twins].
作者信息
Li Qiu-Ying, Zhang Hui, Chen Qian, Shi Bi-Jun, Tan Xiao-Hua, Cui Qi-Liang
机构信息
Department of Neonatology, Third Affiliated Hospital of Guangzhou Medical University/Guangzhou Key Laboratory of Neonatal Intestinal Diseases, Guangzhou 510150, China (Zhang H, Email: zhanghuigz@126. com).
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2023 Dec 15;25(12):1239-1245. doi: 10.7499/j.issn.1008-8830.2307034.
OBJECTIVES
To explore the association between assisted reproductive technology (ART) and birth weight discordance in twins (BWDT).
METHODS
A retrospective analysis was conducted on twin infants born between January 2011 and December 2020 at the Third Affiliated Hospital of Guangzhou Medical University, with complete basic birth data. The impact of ART on the occurrence of BWDT was identified by the multivariate logistic regression analysis.
RESULTS
A total of 3 974 pairs of twins were included, with 1 431 conceived naturally and 2 543 through ART. Neonates in the ART group had higher birth weights than those in the naturally conceived group (<0.001). The incidence of BWDT was lower in the ART group compared to the naturally conceived group (16.17% vs 21.09%, <0.001). The multivariate logistic regression analysis, adjusting for confounding factors such as maternal age, parity, pre-pregnancy body mass index, gestational diabetes, hypothyroidism, gestational age, and chorionic properties, showed no significant difference in the risk of BWDT between the ART and naturally conceived groups (>0.05).
CONCLUSIONS
ART is not associated with the risk of BWDT.
目的
探讨辅助生殖技术（ART）与双胎出生体重不一致（BWDT）之间的关联。
方法
对2011年1月至2020年12月在广州医科大学附属第三医院出生的双胎婴儿进行回顾性分析，这些婴儿有完整的基本出生数据。通过多因素逻辑回归分析确定ART对BWDT发生的影响。
结果
共纳入3974对双胞胎，其中1431对为自然受孕，2543对通过ART受孕。ART组新生儿出生体重高于自然受孕组（<0.001）。与自然受孕组相比，ART组BWDT的发生率较低（16.17%对21.09%，<0.001）。在调整了产妇年龄、产次、孕前体重指数、妊娠期糖尿病、甲状腺功能减退、孕周和绒毛膜性质等混杂因素后，多因素逻辑回归分析显示，ART组和自然受孕组BWDT的风险无显著差异（>0.05）。
结论
ART与BWDT的风险无关。
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