Nataf C, Feldmann G, Lebrec D, Degott C, Descamps J M, Rueff B, Benhamou J P
Gut. 1979 Jun;20(6):531-7. doi: 10.1136/gut.20.6.531.
We report the cases of two renal transplant recipients suffering from idopathic portal hypertension, a condition characterised by increased portal venous pressure in the absence of both histological lesion of the liver and obstruction of the portal vein. In these two patients, perisnusoidal fibrosis, invisible by light microscopy, was demonstrated by electron microscopy; it is suggested that partial obstruction of hepatic sinusoids by perisinusoidal fibrosis could be the mechanism for increased portal venous pressure in all the patients with idiopathic portal hypertension. In these two patients, who received 6-mercaptopurine and azathioprine, perisinusoidal fibrosis might be the consequence of prolonged administration of these drugs.
我们报告了两例患有特发性门静脉高压症的肾移植受者病例，该病症的特征是在没有肝脏组织学病变和门静脉阻塞的情况下门静脉压力升高。在这两名患者中，光镜下不可见的窦周纤维化通过电子显微镜得以证实；有人提出，窦周纤维化导致的肝血窦部分阻塞可能是所有特发性门静脉高压症患者门静脉压力升高的机制。在这两名接受6-巯基嘌呤和硫唑嘌呤治疗的患者中，窦周纤维化可能是长期使用这些药物的结果。
