Shepherd P, Harrison D J
Department of Haematology, Western General Hospital, Edinburgh.
J Clin Pathol. 1990 Mar;43(3):206-10. doi: 10.1136/jcp.43.3.206.
Four patients developed clinically important portal hypertension with histological features of idiopathic portal hypertension while they were receiving cytotoxic drugs for chronic myeloid leukaemia and Hodgkin's disease. Mild sclerosis of some small portal triads was the only abnormality seen at light microscopical examination in three of the four cases. In the remaining case light microscopical findings seemed to be normal. Two cases examined by electron microscopy showed perisinusoidal fibrosis; in one case this was the only abnormality detected. There is an association between idiopathic portal hypertension and the use of chemotherapeutic agents, particularly thioguanine. Adequate histological examination of liver tissue, including electron microscopic studies, is recommended for patients who develop hepatic problems while receiving cytotoxic treatment to elucidate this problem.
四名患者在接受治疗慢性粒细胞白血病和霍奇金病的细胞毒性药物期间，出现了具有特发性门静脉高压组织学特征的临床上重要的门静脉高压。在这四名患者中的三名患者中，光镜检查仅发现一些小门静脉三联征轻度硬化。在其余病例中，光镜检查结果似乎正常。两例经电子显微镜检查显示肝窦周围纤维化；其中一例这是检测到的唯一异常。特发性门静脉高压与化疗药物的使用之间存在关联，尤其是硫鸟嘌呤。对于在接受细胞毒性治疗时出现肝脏问题的患者，建议进行包括电子显微镜研究在内的肝组织充分组织学检查，以阐明这个问题。
