前列腺癌患者预后基因特征的系统评价与综合分析

Systematic review and integrated analysis of prognostic gene signatures for prostate cancer patients.

作者信息

An Yang, Lu Wenyuan, Li Shijia, Lu Xiaoyan, Zhang Yuanyuan, Han Dongcheng, Su Dingyuan, Jia Jiaxin, Yuan Jiaxin, Zhao Binbin, Tu Mengjie, Li Xinyu, Wang Xiaoqing, Fang Na, Ji Shaoping

机构信息

School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.

Department of Biochemistry and Molecular Biology, Cell Signal Transduction Laboratory, School of Basic Medical Sciences, Henan University, Jinming Street, Kaifeng, 475004, Henan, China.

出版信息

Discov Oncol. 2023 Dec 19;14(1):234. doi: 10.1007/s12672-023-00847-4.

DOI:10.1007/s12672-023-00847-4

PMID:38112859

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10730790/

Abstract

Prostate cancer (PC) is one of the most common cancers in men and becoming the second leading cause of cancer fatalities. At present, the lack of effective strategies for prognosis of PC patients is still a problem to be solved. Therefore, it is significant to identify potential gene signatures for PC patients' prognosis. Here, we summarized 71 different prognostic gene signatures for PC and concluded 3 strategies for signature construction after extensive investigation. In addition, 14 genes frequently appeared in 71 different gene signatures, which enriched in mitotic and cell cycle. This review provides extensive understanding and integrated analysis of current prognostic signatures of PC, which may help researchers to construct gene signatures of PC and guide future clinical treatment.

摘要

前列腺癌（PC）是男性中最常见的癌症之一，并且正成为癌症死亡的第二大主要原因。目前，缺乏针对PC患者预后的有效策略仍是一个有待解决的问题。因此，识别PC患者预后的潜在基因特征具有重要意义。在此，我们总结了71种不同的PC预后基因特征，并在广泛研究后得出了3种特征构建策略。此外，有14个基因频繁出现在71种不同的基因特征中，这些基因富集于有丝分裂和细胞周期。本综述对PC目前的预后特征提供了广泛的理解和综合分析，这可能有助于研究人员构建PC的基因特征并指导未来的临床治疗。