Borzenko V G, Gorbachev A A, Dumanskiĭ Iu V, Orlova S M, Shevchenko V V
Vopr Med Khim. 1986 Nov-Dec;32(6):52-4.
Biosynthesis of pyrimidine nucleotides was intensified in proliferating tissues. Age-dependent alterations in activities of thymidine kinase and thymidine phosphorylase were found in healthy persons of 17-70 years old. Distinct increase in activity of thymidine kinase was observed in patients with gastric ulcer but the activity was decreased with ageing. Alterations in the ratio between anabolic and catabolic reactions involving thymidine were studied also in patients with gastric tumor depending on age.
嘧啶核苷酸的生物合成在增殖组织中增强。在17至70岁的健康人群中发现了胸苷激酶和胸苷磷酸化酶活性随年龄的变化。在胃溃疡患者中观察到胸苷激酶活性明显增加，但该活性随年龄增长而降低。还根据年龄研究了胃癌患者中涉及胸苷的合成代谢和分解代谢反应之间的比率变化。
