Günther K, Winnefeld K, Stein G, Sperschneider H, Schröter H, Fünfstück R
Z Urol Nephrol. 1986 Oct;79(10):569-76.
In 2 patients with a progressive dialysis encephalopathy and increased serum aluminium concentrations a Desferal-treatment with 500 mg per week was performed and in these cases the kinetics of Al, Fe, Cu was investigated. After the application of Desferal an increase of the serum levels, the ultrafiltrable proportion, the dialysance and the eliminated quantity of aluminium developed. In the course of the treatment in the two patients the aluminium level could be reduced to approximately normal values. Nevertheless one patient died of a severe course of a progressive dialysis encephalopathy. An increase of the copper concentration independent of Desferal-treatment after the dialysator passage remained without influence on the course of concentration of the serum copper in the examination period. A remarkable effect of the Desferal-therapy on the iron metabolism could not be established. Since in the dosage used there did not appear any side effects the Desferal-application is to characterized as a distinct and effective technique for the decrease of the serum-aluminium-concentration in patients undergoing dialysis.
对2例患有进行性透析性脑病且血清铝浓度升高的患者，每周给予500毫克去铁胺进行治疗，并对这些病例中铝、铁、铜的动力学进行了研究。应用去铁胺后，血清水平、可超滤比例、透析率和铝的清除量均有所增加。在两名患者的治疗过程中，铝水平可降至大致正常范围。然而，一名患者死于进行性透析性脑病的严重病程。透析器通过后，与去铁胺治疗无关的铜浓度升高在检查期间对血清铜浓度的变化过程没有影响。未证实去铁胺疗法对铁代谢有显著影响。由于所用剂量未出现任何副作用，去铁胺的应用可被视为降低透析患者血清铝浓度的一种明确且有效的技术。
