Seland J H, Chylack L T
Acta Ophthalmol (Copenh). 1986 Oct;64(5):533-9. doi: 10.1111/j.1755-3768.1986.tb06968.x.
The morphological changes observed in rabbit lenses incubated without corpus vitreum in medium whose glucose concentration varied cyclically between normoglycaemia and hyperglycaemia were analyzed for the location of light scattering vacuoles. Minimal changes were seen in the epithelial cells, the external bow fibres and the lens nucleus, while maximal changes with vacuolization and damage were seen in the posterior part of the inner bow fibres. It was shown that the exchange of water takes place mainly across the posterior capsule. The susceptibility of this region in part may be due to the low aldose reductase activity in this region of the lens.
分析了在葡萄糖浓度在正常血糖和高血糖之间周期性变化的培养基中无玻璃体孵育的兔晶状体的形态学变化，以确定光散射空泡的位置。在上皮细胞、外弓形纤维和晶状体核中观察到的变化最小，而在内弓形纤维后部观察到空泡化和损伤的最大变化。结果表明，水的交换主要发生在后囊膜。该区域的易感性部分可能是由于晶状体该区域醛糖还原酶活性较低。
