Antitumor activity and biochemistry of novel analogs of the antibiotic, CC-1065.

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作者信息

Wierenga W, Bhuyan B K, Kelly R C, Krueger W C, Li L H, McGovren J P, Swenson D H, Warpehoski M A

出版信息

Adv Enzyme Regul. 1986;25:141-55. doi: 10.1016/0065-2571(86)90012-9.

DOI:10.1016/0065-2571(86)90012-9

PMID:3812082

Abstract

摘要

相似文献

Antitumor activity and biochemistry of novel analogs of the antibiotic, CC-1065.

Adv Enzyme Regul. 1986;25:141-55. doi: 10.1016/0065-2571(86)90012-9.

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Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065.基于CC-1065的合成抗肿瘤药物生物活性及DNA相互作用的立体电子因素

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Determination of the structural features of (+)-CC-1065 that are responsible for bending and winding of DNA.确定负责使DNA弯曲和缠绕的（+）-CC-1065的结构特征。

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Structure and activity relationship of several novel CC-1065 analogs.

Invest New Drugs. 1987 Dec;5(4):329-37. doi: 10.1007/BF00169971.

CC-1065 (NSC 298223), a novel antitumor agent that interacts strongly with double-stranded DNA.CC-1065（NSC 298223），一种能与双链DNA强烈相互作用的新型抗肿瘤药物。

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Interaction of CC-1065 and its analogues with mouse DNA and chromatin.CC-1065及其类似物与小鼠DNA和染色质的相互作用。

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Effects of U-71,184 and several other CC-1065 analogues on cell survival and cell cycle of Chinese hamster ovary cells.U-71,184及其他几种CC-1065类似物对中国仓鼠卵巢细胞存活及细胞周期的影响。

Cancer Res. 1988 Jan 1;48(1):109-16.

DNA sequence recognition by the antitumor antibiotic CC-1065 and analogs of CC-1065.

Chem Biol Interact. 1991;79(3):265-86. doi: 10.1016/0009-2797(91)90109-k.

Mechanism of interaction of CC-1065 (NSC 298223) with DNA.CC-1065（NSC 298223）与DNA的相互作用机制。

Cancer Res. 1982 Jul;42(7):2821-8.

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Structure and activity relationship of several novel CC-1065 analogs.

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Adozelesin, a selected lead among cyclopropylpyrroloindole analogs of the DNA-binding antibiotic, CC-1065.阿多西嗪，一种从DNA结合抗生素CC - 1065的环丙基吡咯并吲哚类似物中筛选出的先导化合物。

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