Department of Pathology, Donostia University Hospital, San Sebastian, Spain.
Department of Pathology, University Hospital of Navarra, Pamplona, Spain.
Int J Surg Pathol. 2024 Sep;32(6):1134-1139. doi: 10.1177/10668969231213387. Epub 2023 Nov 20.
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of intermediate malignancy and uncertain differentiation. To date, only four patients diagnosed with AFH located in the chest wall have been described. Herein, we describe a 44-year-old woman diagnosed with breast infiltrating lobular carcinoma. During the imaging study with positron emission tomography-computerized tomography scan, a 4 cm solid lesion located in the chest wall was identified. Fine-needle aspiration followed by surgical excision with intraoperative frozen section study was performed. The combined histomorphologic, immunohistochemical, and molecular findings confirmed the diagnosis of AFH. In this report, we describe, to the best of our knowledge, the first patient with synchronous AFH and breast cancer.
血管外皮细胞瘤样纤维组织细胞瘤（AFH）是一种罕见的软组织肿瘤，具有中等恶性和不确定的分化。迄今为止，仅描述了 4 例位于胸壁的 AFH 患者。在此，我们描述了一位 44 岁的女性，被诊断为乳腺浸润性小叶癌。在正电子发射断层扫描-计算机断层扫描研究中，发现了一个位于胸壁的 4cm 实性病变。进行了细针抽吸，随后进行了手术切除，并进行了术中冷冻切片研究。结合组织形态学、免疫组织化学和分子研究结果，确诊为 AFH。在本报告中，据我们所知，我们描述了首例同时患有 AFH 和乳腺癌的患者。
