Muğla Sıtkı Koçman University.
Acta Chim Slov. 2023 Nov 23;70(4):620-627. doi: 10.17344/acsi.2023.8398.
The research focuses on investigating the cytotoxic effects of Cu(II) complexes bearing isatine groups on cancer cells. These complexes were tested against lung carcinoma (A549) and breast carcinoma (MCF-7) cell lines using the MTT assay, with cisplatin as a positive control. Additionally, their effects on human normal cell line 3T3 were assessed. The Cu(L1)2 complex exhibited significant inhibitory effects on tumor cells in a dose-dependent manner, although not as potent as cisplatin. The cytotoxic selectivity indices (SI) indicated acceptable selectivity levels for both cancer cell lines, indicating potential for selective lethality. The crystal structure of one compound was confirmed, revealing van der Waals interactions and hydrogen bonding in the packing.
本研究专注于研究含吲哚基团的 Cu(II) 配合物对癌细胞的细胞毒性作用。采用 MTT 法，以顺铂为阳性对照，对这些配合物进行了肺癌（A549）和乳腺癌（MCF-7）细胞系的测试。此外，还评估了它们对人正常细胞系 3T3 的影响。Cu(L1)2 配合物对肿瘤细胞表现出显著的剂量依赖性抑制作用，尽管不如顺铂有效。细胞毒性选择性指数 (SI) 表明两种癌细胞系都具有可接受的选择性水平，表明具有潜在的选择性致死性。一个化合物的晶体结构得到了确认，揭示了在包装中的范德华相互作用和氢键。
