Cohen H J, Bernstein R J, Grufferman S
Am J Hematol. 1987 Feb;24(2):119-26. doi: 10.1002/ajh.2830240202.
A hospital-based case-control study of 153 multiple myeloma (MM) cases and 459 controls was conducted to evaluate the hypothesis that chronic or frequent infections or allergic and autoimmune diseases might be of higher prevalence in individuals who develop MM. Information was obtained by direct interviews of subjects. Controls were matched to cases on age, sex, race, and hospital. "Immune-stimulating conditions" included chronic infections such as pyelonephritis, urinary tract infections (UTIs), prostatitis, rheumatoid arthritis and other collagen vascular diseases, allergies, bronchitis, tuberculosis, cholecystitis, diverticulitis, and osteomyelitis. The overall odds ratio (OR) (odds of history of immune-stimulating conditions in cases versus controls) was 0.4 (95% confidence interval = 0.3-0.7) which suggested that cases had significantly less immune-stimulating conditions than did controls. The exposure rate for these conditions was high for cases (0.7) as well as for all control groups (0.8). These findings suggest that immune-stimulating conditions alone are not the causative factor in the etiology of MM, though they may play a role in the predisposed individual.
开展了一项基于医院的病例对照研究，纳入153例多发性骨髓瘤（MM）患者和459名对照，以评估慢性或频繁感染、过敏性和自身免疫性疾病在罹患MM个体中可能具有更高患病率这一假说。通过对研究对象进行直接访谈获取信息。对照在年龄、性别、种族和医院方面与病例进行匹配。“免疫刺激状况”包括慢性感染，如肾盂肾炎、尿路感染（UTI）、前列腺炎、类风湿关节炎和其他胶原血管疾病、过敏、支气管炎、结核病、胆囊炎、憩室炎和骨髓炎。总体比值比（OR）（病例组与对照组中免疫刺激状况病史的比值）为0.4（95%置信区间 = 0.3 - 0.7），这表明病例组的免疫刺激状况显著少于对照组。病例组以及所有对照组中这些状况的暴露率都很高（病例组为0.7，对照组为0.8）。这些发现表明，仅免疫刺激状况并非MM病因中的致病因素，尽管它们可能在易感个体中发挥作用。
