Li Jie-Qiong, Zhang Ya-Ru, Wang Hui-Fu, Guo Yu, Shen Xue-Ning, Li Meng-Meng, Song Jing-Hui, Tan Lan, Xie An-Mu, Yu Jin-Tai
Department of Neurology the Affiliated Hospital of Qingdao University Qingdao China.
Department of Neurology and National Center for Neurological Disorders Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Shanghai Medical College Fudan University Shanghai China.
Alzheimers Dement (Amst). 2023 Dec 19;15(4):e12517. doi: 10.1002/dad2.12517. eCollection 2023 Oct-Dec.
We analyzed relationships among peripheral immunity markers, cognition, Alzheimer's disease (AD)-related biomarkers, and neuroimaging to understand peripheral immunity involvement in AD.
Peripheral immunity markers were assessed in AD, non-AD neurodegenerative disorders, and controls, examining their connections with cognition, AD-related biomarkers, and neuroimaging using multiple regression models.
The study included 1579 participants. Higher levels of white blood cell, neutrophil, monocyte, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and lower lymphocyte-to-monocyte ratio (LMR) were associated with cognitive decline and more severe anxiety and depression. The impact of lower LMR, lymphocyte count, and higher NLR on cognitive decline is mediated through cerebrospinal fluid amyloid beta (Aβ) levels. Additionally, increased PLR, NLR, and SII were associated with brain atrophy and hippocampal Aβ deposition (amyloid positron emission tomography).
Peripheral immunity markers offer a non-invasive and cost-effective means of studying AD-related pathophysiological changes, providing valuable insights into its pathogenesis and treatment.
Peripheral immunity markers linked to cognitive decline and anxiety/depression.Low LMR, LYM, and high NLR linked to reduced CSF Aβ, impacting cognition.High PLR, NLR, SII associated with brain atrophy and hippocampal Aβ deposition.
我们分析了外周免疫标记物、认知、阿尔茨海默病（AD）相关生物标志物和神经影像学之间的关系，以了解外周免疫在AD中的作用。
在AD、非AD神经退行性疾病和对照组中评估外周免疫标记物，使用多元回归模型研究它们与认知、AD相关生物标志物和神经影像学的联系。
该研究纳入了1579名参与者。白细胞、中性粒细胞、单核细胞、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、全身免疫炎症指数（SII）水平较高，淋巴细胞与单核细胞比值（LMR）较低，与认知功能下降以及更严重的焦虑和抑郁相关。较低的LMR、淋巴细胞计数和较高的NLR对认知功能下降的影响是通过脑脊液淀粉样蛋白β（Aβ）水平介导的。此外，PLR、NLR和SII升高与脑萎缩和海马Aβ沉积（淀粉样蛋白正电子发射断层扫描）相关。
外周免疫标记物为研究AD相关病理生理变化提供了一种非侵入性且具有成本效益的方法，为其发病机制和治疗提供了有价值的见解。
外周免疫标记物与认知功能下降和焦虑/抑郁相关。低LMR、LYM和高NLR与脑脊液Aβ减少相关，影响认知。高PLR、NLR、SII与脑萎缩和海马Aβ沉积相关。
