Harder F, Floersheim G L, Jeekel J, vd Linden C, Mihatsch M J, Rüedi T, Tondelli P
Helv Chir Acta. 1979 May;46(1-2):219-23.
Donorspecific recipient conditioning in the non-related beagle produces prolonged kidney-graft survival without any postoperative immunosuppression. Besides 2 donor blood injections on days--18 and--11 followed by a 6-day preoperative immunosuppressive pulse (Procarbazine, ATS) donor plasma and a donor liver preparation are equally active. Additional long-term low dose preoperative immunosuppression with azathioprine tends to strengthen the effect. Lymphocytotoxic antibody formation is avoided in the recipient where no whole blood is used.
在非亲缘关系的比格犬中进行供体特异性受体预处理可使肾移植存活期延长，且术后无需任何免疫抑制。除了在第-18天和-11天注射2次供体血液，随后进行为期6天的术前免疫抑制冲击治疗（丙卡巴肼、抗胸腺细胞血清）外，供体血浆和供体肝脏制剂同样有效。术前额外使用硫唑嘌呤进行长期低剂量免疫抑制往往会增强效果。在不使用全血的受体中可避免淋巴细胞毒性抗体的形成。
