老年人呼吸道合胞病毒疫苗接种：运用3C模型解决疫苗犹豫问题。
RSV vaccination in older adults: Addressing vaccine hesitancy using the 3C model.
作者信息
Houle Sherilyn K D, Andrew Melissa K
机构信息
School of Pharmacy, University of Waterloo, Waterloo, Ontario.
Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia.
出版信息
Can Pharm J (Ott). 2023 Nov 24;157(1):39-44. doi: 10.1177/17151635231210879. eCollection 2024 Jan-Feb.
Abstract
The first vaccine against respiratory syncytial virus (RSV) targeting older adults was approved for use in Canada in August 2023. As a frequent first point of contact for Canadians seeking advice on vaccination and the most common setting for the administration of influenza vaccines, community pharmacies will also play a role in RSV vaccination efforts. To address vaccine hesitancy confidently and effectively, pharmacists must be equipped with knowledge of the factors that affect a person's decision on whether to be vaccinated or not. The 3C Model of Vaccine Hesitancy summarizes these as complacency, confidence and convenience. This article introduces the model and describes the often-underrecognized relevance of RSV to older adults, including risk factors and burden of disease. It also reviews the history and status of vaccine development and approval and presents clinical trial data to equip pharmacists to discuss RSV vaccination with older adults who express vaccine hesitancy.
摘要
首款针对老年人的呼吸道合胞病毒（RSV）疫苗于2023年8月在加拿大获批使用。作为加拿大人寻求疫苗接种建议的常见首要接触点以及流感疫苗接种的最常见场所，社区药房也将在RSV疫苗接种工作中发挥作用。为了自信且有效地应对疫苗犹豫问题，药剂师必须掌握影响人们是否接种疫苗决策的因素相关知识。疫苗犹豫的3C模型将这些因素概括为自满、信心和便利。本文介绍了该模型，并描述了RSV对老年人常常未得到充分认识的相关性，包括风险因素和疾病负担。文章还回顾了疫苗研发和获批的历史与现状，并呈现临床试验数据，以使药剂师有能力与表达疫苗犹豫的老年人讨论RSV疫苗接种问题。
相似文献
1
RSV vaccination in older adults: Addressing vaccine hesitancy using the 3C model.老年人呼吸道合胞病毒疫苗接种：运用3C模型解决疫苗犹豫问题。
Can Pharm J (Ott). 2023 Nov 24;157(1):39-44. doi: 10.1177/17151635231210879. eCollection 2024 Jan-Feb.
2
Clinical and economic outcomes associated with respiratory syncytial virus vaccination in older adults in the United States.与美国老年人呼吸道合胞病毒疫苗接种相关的临床和经济结局。
Vaccine. 2022 Jan 24;40(3):483-493. doi: 10.1016/j.vaccine.2021.12.002. Epub 2021 Dec 20.
3
Understanding Drivers of Vaccine Hesitancy During the COVID-19 Pandemic Among Older Adults in Jiangsu Province, China: Cross-sectional Survey.了解中国江苏省老年人在新冠疫情期间疫苗犹豫的驱动因素：横断面调查
JMIR Form Res. 2023 Feb 7;7:e39994. doi: 10.2196/39994.
4
Evaluation of intentions to get vaccinated against influenza, COVID 19, pertussis and to get a future vaccine against respiratory syncytial virus in pregnant women.评估孕妇接种流感、COVID-19、百日咳疫苗和未来接种呼吸道合胞病毒疫苗的意愿。
Vaccine. 2023 Nov 30;41(49):7342-7347. doi: 10.1016/j.vaccine.2023.10.067. Epub 2023 Nov 12.
5
Prospective Attitudes towards Respiratory Syncytial Virus (RSV) Vaccination: Validation of a Survey Instrument among Young Females in Jordan Pending Vaccine Authorization.对呼吸道合胞病毒（RSV）疫苗接种的前瞻性态度：约旦年轻女性中一份调查问卷工具在疫苗授权前的验证
Vaccines (Basel). 2023 Aug 19;11(8):1386. doi: 10.3390/vaccines11081386.
6
[Influenza vaccine hesitancy among health workers, Bahia State, Brazil].[巴西巴伊亚州医护人员对流感疫苗的犹豫态度]
Cad Saude Publica. 2022 Jan 31;38(1):e00098521. doi: 10.1590/0102-311X00098521. eCollection 2022.
7
Factors associated with caregivers' hesitancy to vaccinate children against influenza: A cross-sectional survey in China.与照顾者对接种儿童流感疫苗犹豫不决相关的因素：中国的一项横断面调查。
Vaccine. 2022 Jun 23;40(29):3975-3983. doi: 10.1016/j.vaccine.2022.05.023. Epub 2022 May 28.
8
Safety and Immunogenicity of the Ad26.RSV.preF Investigational Vaccine Coadministered With an Influenza Vaccine in Older Adults.在老年人中联合使用流感疫苗的 Ad26.RSV.preF 研究性疫苗的安全性和免疫原性。
J Infect Dis. 2021 Feb 24;223(4):699-708. doi: 10.1093/infdis/jiaa409.
9
Modeling Respiratory Syncytial Virus Adult Vaccination in the United States With a Dynamic Transmission Model.用动态传播模型对美国呼吸道合胞病毒成人疫苗接种进行建模。
Clin Infect Dis. 2023 Aug 14;77(3):480-489. doi: 10.1093/cid/ciad161.
10
Trust, influence, and community: Why pharmacists and pharmacies are central for addressing vaccine hesitancy.信任、影响力和社区：为什么药剂师和药店是解决疫苗犹豫的核心。
J Am Pharm Assoc (2003). 2022 Jan-Feb;62(1):305-308. doi: 10.1016/j.japh.2021.10.001. Epub 2021 Oct 8.
引用本文的文献
1
A process evaluation of Ontario, Canada's 2023-24 older-adult RSV vaccination program.对加拿大安大略省2023 - 2024年老年人呼吸道合胞病毒疫苗接种计划的过程评估。
Hum Vaccin Immunother. 2025 Dec;21(1):2550089. doi: 10.1080/21645515.2025.2550089. Epub 2025 Aug 25.
2
Exploring Patient Trust in Healthcare Provider Influenza Vaccine Information and Recommendations in a Medically Underserved Area of Washington State.在华盛顿州一个医疗服务不足地区，探索患者对医疗服务提供者流感疫苗信息及建议的信任度。
Vaccines (Basel). 2025 May 10;13(5):505. doi: 10.3390/vaccines13050505.
3
Prevention of respiratory syncytial virus disease across the lifespan in Italy.意大利全生命周期呼吸道合胞病毒疾病的预防
Pneumonia (Nathan). 2025 Apr 5;17(1):8. doi: 10.1186/s41479-025-00160-4.
4
Knowledge, attitude, and perception regarding the respiratory syncytial virus vaccine among healthcare professionals.医护人员对呼吸道合胞病毒疫苗的知识、态度和认知
J Pharm Policy Pract. 2025 Mar 28;18(1):2482669. doi: 10.1080/20523211.2025.2482669. eCollection 2025.
5
Vaccine and therapeutic agents against the respiratory syncytial virus: resolved and unresolved issue.抗呼吸道合胞病毒的疫苗和治疗药物：已解决和未解决的问题
MedComm (2020). 2024 Nov 21;5(12):e70016. doi: 10.1002/mco2.70016. eCollection 2024 Dec.
6
From vaccine hesitancy to vaccine motivation: A motivational interviewing based approach to vaccine counselling.从疫苗犹豫到疫苗动机：基于动机性访谈的疫苗咨询方法。
Hum Vaccin Immunother. 2024 Dec 31;20(1):2391625. doi: 10.1080/21645515.2024.2391625. Epub 2024 Aug 26.
本文引用的文献
1
Summary of the National Advisory Committee on Immunization (NACI) statement update on the recommended use of palivizumab to reduce complications of respiratory syncytial virus infection in infants.国家免疫咨询委员会（NACI）关于推荐使用帕利珠单抗降低婴儿呼吸道合胞病毒感染并发症的声明更新摘要。
Can Commun Dis Rep. 2022 Jul 7;48(7-8):363-366. doi: 10.14745/ccdr.v48i78a08.
2
Attitudes of Swedish Language Twitter Users Toward COVID-19 Vaccination: Exploratory Qualitative Study.瑞典语推特用户对新冠疫苗接种的态度：探索性定性研究
JMIR Infodemiology. 2023 Feb 22;3:e42357. doi: 10.2196/42357. eCollection 2023.
3
Incidence of Guillain-Barré Syndrome post COVID-19: a systematic review of case reports and case series.新冠病毒感染后吉兰-巴雷综合征的发病率：病例报告和病例系列的系统评价。
Eur Rev Med Pharmacol Sci. 2023 Mar;27(5):2152-2164. doi: 10.26355/eurrev_202303_31588.
4
Mitigating Vaccine Hesitancy and Building Trust to Prevent Future Measles Outbreaks in England.缓解疫苗犹豫情绪并建立信任以预防英国未来的麻疹疫情。
Vaccines (Basel). 2023 Jan 28;11(2):288. doi: 10.3390/vaccines11020288.
5
The Journey to RSV Vaccines - Heralding an Era of Structure-Based Design.呼吸道合胞病毒疫苗的征程——开创基于结构设计的时代。
N Engl J Med. 2023 Feb 16;388(7):579-581. doi: 10.1056/NEJMp2216358.
6
Respiratory syncytial virus disease burden in adults aged 60 years and older in high-income countries: A systematic literature review and meta-analysis.高收入国家 60 岁及以上成年人呼吸道合胞病毒疾病负担：系统文献回顾和荟萃分析。
Influenza Other Respir Viruses. 2023 Jan;17(1):e13031. doi: 10.1111/irv.13031. Epub 2022 Nov 11.
7
Change in functional status associated with respiratory syncytial virus infection in hospitalized older adults.与住院老年人呼吸道合胞病毒感染相关的功能状态变化。
Influenza Other Respir Viruses. 2022 Nov;16(6):1151-1160. doi: 10.1111/irv.13043. Epub 2022 Sep 7.
8
Impact of respiratory viral infections on mortality and critical illness among hospitalized patients with chronic obstructive pulmonary disease.呼吸道病毒感染对慢性阻塞性肺疾病住院患者死亡率和重症的影响。
Influenza Other Respir Viruses. 2022 Nov;16(6):1172-1182. doi: 10.1111/irv.13050. Epub 2022 Sep 7.
9
Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape.呼吸道合胞病毒预防近在咫尺：疫苗和单克隆抗体领域。
Lancet Infect Dis. 2023 Jan;23(1):e2-e21. doi: 10.1016/S1473-3099(22)00291-2. Epub 2022 Aug 8.
10
Doubt in store: vaccine hesitancy among grocery workers during the COVID-19 pandemic.质疑不断：新冠疫情期间杂货店员工对接种疫苗犹豫不决。
J Behav Med. 2023 Apr;46(1-2):167-178. doi: 10.1007/s10865-021-00276-0. Epub 2022 Apr 30.
Zotero 插件