miRNAs 和假基因来源的 lncRNAs 在人类癌症中的病理作用及其作为预后/诊断生物标志物的比较。

Pathological roles of miRNAs and pseudogene-derived lncRNAs in human cancers, and their comparison as prognosis/diagnosis biomarkers.

机构信息

Department of Cellular and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.

Department of Animal Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

出版信息

Pathol Res Pract. 2024 Jan;253:155014. doi: 10.1016/j.prp.2023.155014. Epub 2023 Dec 12.

DOI:10.1016/j.prp.2023.155014

PMID:38128189

Abstract

This review examines and compares the diagnostic and prognostic capabilities of miRNAs and lncRNAs derived from pseudogenes in cancer patients. Additionally, it delves into their roles in cancer pathogenesis. Both miRNAs and pseudogene-derived lncRNAs have undergone thorough investigation as remarkably sensitive and specific cancer biomarkers, offering significant potential for cancer detection and monitoring. . Extensive research is essential to gain a complete understanding of the precise roles these non-coding RNAs play in cancer, allowing the development of novel targeted therapies and biomarkers for improved cancer detection and treatment approaches.

摘要

本综述考察并比较了源自癌症患者假基因的 miRNA 和 lncRNA 的诊断和预后能力。此外，还探讨了它们在癌症发病机制中的作用。miRNA 和假基因衍生的 lncRNA 作为极具敏感性和特异性的癌症生物标志物，已经得到了广泛的研究，为癌症的检测和监测提供了巨大的潜力。为了全面了解这些非编码 RNA 在癌症中的确切作用，需要进行广泛的研究，从而开发新的靶向治疗方法和生物标志物，以改善癌症的检测和治疗方法。