Centre de Recherche en Cancérologie de Lyon, CNRS UMR5286, Inserm U1052, Université de Lyon, Lyon, France.
Institut de Génomique Fonctionnelle de Lyon, UMR5242, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard-Lyon 1, Lyon, France.
Oncogene. 2024 Feb;43(6):379-387. doi: 10.1038/s41388-023-02899-w. Epub 2023 Dec 21.
Cell migration is essential throughout the life of multicellular organisms, and largely depends on the spatial and temporal regulation of cytoskeletal dynamics, cell adhesion and signal transduction. Interestingly, Estrogen-related receptor alpha (ERRα) has been identified as a major regulator of cell migration in both physiological and pathological conditions. ERRα is an orphan member of the nuclear hormone receptor superfamily of transcription factors and displays many biological functions. ERRα is a global regulator of energy metabolism, and it is also highly involved in bone homeostasis, development, differentiation, immunity and cancer progression. Importantly, in some instances, the regulation of these biological processes relies on the ability to orchestrate cell movements. Therefore, this review describes how ERRα-mediated cell migration contributes not only to tissue homeostasis but also to tumorigenesis and metastasis, and highlights the molecular and cellular mechanisms by which ERRα finely controls the cell migratory potential.
细胞迁移是多细胞生物生命过程中的基本活动，在很大程度上依赖于细胞骨架动力学、细胞黏附和信号转导的时空调节。有趣的是，雌激素相关受体α（ERRα）已被确定为生理和病理条件下细胞迁移的主要调节因子。ERRα 是核激素受体转录因子超家族的孤儿成员，具有许多生物学功能。ERRα 是能量代谢的全局调节剂，它还高度参与骨稳态、发育、分化、免疫和癌症进展。重要的是，在某些情况下，这些生物学过程的调节依赖于协调细胞运动的能力。因此，本文描述了 ERRα 介导的细胞迁移如何不仅有助于组织稳态，而且有助于肿瘤发生和转移，并强调了 ERRα 精细控制细胞迁移潜力的分子和细胞机制。
