Ramboatiana R, Monnin L, Thévenon F, Billot R, Schoch J P, Tuefferd B, Tartary D, Robert R
Ann Fr Anesth Reanim. 1986;5(5):469-72. doi: 10.1016/s0750-7658(86)80030-2.
A double blind study has been carried out on patients scheduled for appendicectomy. They were divided into two groups who were given diazepam as premedication either orally or intramuscularly. The clinical effects were measured with regard to anxiolysis, gastric contents volume and acidity. Orally premedicated patients were not significantly less anxious. No significant differences between both groups concerning gastric contents (volume and pH) were found. Therefore, oral premedication did not increase the risk of inhalation. Taking into account the previous findings in the literature, the pharmacological advantages of the oral route and the lack of complications, a wider use of oral premedication for elective operations in adults is recommended.
对计划进行阑尾切除术的患者进行了一项双盲研究。他们被分为两组，分别通过口服或肌肉注射给予地西泮作为术前用药。从抗焦虑、胃内容物体积和酸度方面对临床效果进行了测量。口服术前用药的患者焦虑程度并没有显著降低。两组在胃内容物（体积和pH值）方面没有发现显著差异。因此，口服术前用药并没有增加吸入风险。考虑到文献中先前的研究结果、口服途径的药理学优势以及无并发症情况，建议在成人择期手术中更广泛地使用口服术前用药。
