绝经后女性在使用促性腺激素释放激素（LRH）类似物进行刺激治疗期间促性腺激素分泌减少。
Reduced gonadotropin secretion in postmenopausal women during treatment with a stimulatory LRH analogue.
作者信息
Bergquist C, Nillius S J, Wide L
出版信息
J Clin Endocrinol Metab. 1979 Sep;49(3):472-4. doi: 10.1210/jcem-49-3-472.
The potent and long-acting LRH agonist D-Ser(TBU)6-EA10-LRH was administered in a daily subcutaneous dose of 5 microgram to 5 postmenopausal women for a period of 10 days. The LRH analogue produced a significant decrease in both the basal FSH and LH levels and the gonadotropin responses to the agonist. The estrogen levels in serum remained unchanged during the study period. The results suggest that D-Ser(TBU)6-EA10-LRH has a direct inhibitory effect at the pituitary level.
强效长效促黄体激素释放激素（LRH）激动剂D - Ser(TBU)6 - EA10 - LRH以每日5微克的皮下剂量给予5名绝经后女性，持续10天。该LRH类似物使基础促卵泡生成素（FSH）和促黄体生成素（LH）水平以及促性腺激素对该激动剂的反应均显著降低。在研究期间，血清中的雌激素水平保持不变。结果表明，D - Ser(TBU)6 - EA10 - LRH在垂体水平具有直接抑制作用。
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