舌肌电阻抗肌电图与伴有或不伴有舌下神经病变的长期口咽癌幸存者的功能、神经生理学和临床结局指标相关：一项探索性研究。
Tongue electrical impedance myography correlates with functional, neurophysiologic, and clinical outcome measures in long-term oropharyngeal cancer survivors with and without hypoglossal neuropathy: An exploratory study.
作者信息
Hansen Nathan J, Woodman Karin, Buoy Sheila, Mao Shitong, Barbon Carly E A, Lai Stephen Y, Fuller C David, Hutcheson Katherine A, Sanchez Benjamin
机构信息
Department of Electrical and Computer Engineering, The University of Utah, Salt Lake City, Utah, USA.
Department of Neurology, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA.
出版信息
Head Neck. 2024 Mar;46(3):581-591. doi: 10.1002/hed.27618. Epub 2023 Dec 22.
BACKGROUND
This pilot study analyzed correlations between tongue electrical impedance myography (EIM), standard tongue electromyography (EMG), and tongue functional measures in N = 4 long-term oropharyngeal cancer (OPC) survivors.
METHODS
Patients were screened for a supportive care trial (NCT04151082). Hypoglossal nerve function was evaluated with genioglossus needle EMG, functional measures with the Iowa oral performance instrument (IOPI), and multi-frequency tissue composition with tongue EIM.
RESULTS
Tongue EIM conductivity was higher for patients with EMG-confirmed cranial nerve XII neuropathy than those without (p = 0.005) and in patients with mild versus normal EMG reinnervation ratings (16 kHz EIM: p = 0.051). Tongue EIM correlated with IOPI strength measurements (e.g., anterior maximum isometric lingual strength: r = 0.62, p = 0.020).
CONCLUSIONS
Tongue EIM measures related to tongue strength and the presence of XII neuropathy. Noninvasive tongue EIM may be a convenient adjunctive biomarker to assess tongue health in OPC survivors.
背景
本初步研究分析了N = 4例长期口咽癌（OPC）幸存者的舌肌电阻抗肌电图（EIM）、标准舌肌电图（EMG）与舌功能指标之间的相关性。
方法
对患者进行支持性护理试验筛查（NCT04151082）。采用颏舌肌针电极肌电图评估舌下神经功能，使用爱荷华口腔功能仪器（IOPI）评估功能指标，并用舌肌EIM评估多频组织成分。
结果
肌电图证实有第十二对脑神经神经病变的患者，其舌肌EIM电导率高于无病变者（p = 0.005），且在肌电图再支配评级为轻度与正常的患者中也有此差异（16kHz EIM：p = 0.051）。舌肌EIM与IOPI力量测量结果相关（例如，前位最大等长舌肌力量：r = 0.62，p = 0.020）。
结论
舌肌EIM测量结果与舌肌力量及第十二对脑神经病变的存在有关。无创性舌肌EIM可能是评估OPC幸存者舌部健康状况的一种便捷辅助生物标志物。
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