埃塞俄比亚哈拉里地区儿童中沙眼衣原体 Pgp3 抗原的血清学转换。
Seroreversion to Chlamydia trachomatis Pgp3 Antigen Among Children in a Hyperendemic Region of Amhara, Ethiopia.
机构信息
Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA.
The Carter Center Ethiopia, Addis Ababa, Ethiopia.
出版信息
J Infect Dis. 2024 Aug 16;230(2):293-297. doi: 10.1093/infdis/jiad602.
Abstract
Monitoring trachoma transmission with antibody data requires characterization of decay in IgG to Chlamydia trachomatis antigens. In a 3-year longitudinal cohort in a high-transmission setting, we estimated a median IgG half-life of 3 years and a seroreversion rate of 2.5 per 100 person-years (95% confidence interval, 1.6-3.5). Clinical Trials Registration NCT02754583.
摘要
监测沙眼传播需要对沙眼衣原体抗原的 IgG 衰减进行特征描述。在高传播环境下的 3 年纵向队列研究中，我们估计 IgG 的中位半衰期为 3 年，血清学转换率为每 100 人年 2.5 例（95%置信区间，1.6-3.5）。临床试验注册 NCT02754583。
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