Lindahl B, Alm P, Fernö M, Grundsell H, Norgren A, Tropé C
Anticancer Res. 1986 Nov-Dec;6(6):1317-20.
Estradiol and progesterone receptor concentrations were positively correlated to the stage of the disease and to the grade of the tumors, but not to myometrial invasion. Myometrial invasion of more than the inner third and degree of differentiation are both important prognostic factors. By combining low estradiol receptor concentration and the degree of myometrial invasion in poorly differentiated adenocarcinomas, stage I-II, it was possible to identify a group of patients containing a high percentage of relapses. This group consisted of 60% of all patients with poorly differentiated carcinoma stage I-II, who had a relapse rate of almost 50%, and were thus suitable for aggressive initial treatment.
雌二醇和孕酮受体浓度与疾病分期及肿瘤分级呈正相关，但与肌层浸润无关。肌层浸润超过内三分之一和分化程度均为重要的预后因素。对于I-II期低分化腺癌，通过结合低雌二醇受体浓度和肌层浸润程度，有可能识别出一组复发率较高的患者。该组患者占所有I-II期低分化癌患者的60%，复发率近50%，因此适合积极的初始治疗。
