日本奄美群岛地区红糖摄入与癌症风险降低的关联。
Association between brown sugar intake and decreased risk of cancer in the Amami islands region, Japan.
机构信息
School of Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.
Kameda Medical Center, Kamogawa, Japan.
出版信息
Asia Pac J Clin Nutr. 2023 Dec;32(4):426-433. doi: 10.6133/apjcn.202312_32(4).0007.
BACKGROUND AND OBJECTIVES
Although excess white sugar intake imposes various health burdens, brown sugar is high in minerals, polyphenols, and polycosanol. However, few epidemiological studies have assessed brown sugar intake for health benefit. People in the Amami islands region, with a relatively high proportion of individuals with longevity, consume brown sugar as a type of refreshment. This cohort study was conducted in Amami to clarify the association of brown sugar intake with mortality risk and cancer incidence.
METHODS AND STUDY DESIGN
Participants were recruited from the general population of Amami as part of the Japan Multi-Institutional Collaborative Cohort Study. The number of eligible participants was 5004 (2057 men and 2947 women). During the median follow-up period of 13.4 years, 274 deaths and 338 cases of cancer were observed. HRs and 95% CIs were estimated using the Cox proportional hazard model, after adjusting for sugar-related and other variables.
RESULTS
After adjusting for their related confounding factors, brown sugar intake was associated with decreased HRs and a decreasing trend for all-site and stomach cancer incidence (p = 0.001 and 0.017, respectively) in women and men, and for breast cancer incidence (p = 0.034) in women. Additionally, a decreasing trend in the HRs for lung cancer incidence was observed among never and ex-smokers (p = 0.039). Decreased HRs for overall death, cancer, and cardiovascular disease were not apparent.
CONCLUSIONS
Brown sugar intake was associated with decreased risk of all-site, stomach, and breast cancer incidences in the Amami population.
背景和目的
尽管过量摄入白糖会带来各种健康负担，但红糖富含矿物质、多酚和多糖醇。然而，很少有流行病学研究评估过红糖摄入与健康益处之间的关系。奄美群岛地区的人们，长寿者比例相对较高，他们将红糖作为一种提神饮品。本队列研究在奄美地区进行，旨在阐明红糖摄入与死亡率和癌症发病率之间的关联。
方法和研究设计
参与者是从奄美群岛的一般人群中招募的，作为日本多机构合作队列研究的一部分。合格参与者的数量为 5004 人（2057 名男性和 2947 名女性）。在中位数为 13.4 年的随访期间，观察到 274 例死亡和 338 例癌症病例。使用 Cox 比例风险模型估计 HR 和 95%CI，在调整了与糖有关的和其他变量后进行。
结果
在调整了相关混杂因素后，红糖摄入与女性和男性的所有部位和胃癌发病率的 HR 降低和下降趋势相关（p = 0.001 和 0.017），以及女性的乳腺癌发病率（p = 0.034）。此外，在从未吸烟者和前吸烟者中，肺癌发病率的 HR 呈下降趋势（p = 0.039）。总体死亡率、癌症和心血管疾病的 HR 降低不明显。
结论
在奄美人群中，红糖摄入与所有部位、胃癌和乳腺癌发病率降低相关。
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