Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, P. R. China.
State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P. R. China.
Cancer Gene Ther. 2024 Mar;31(3):454-463. doi: 10.1038/s41417-023-00716-w. Epub 2023 Dec 22.
Nasopharyngeal carcinoma (NPC) originates in the epithelial cells of the nasopharynx and is a common malignant tumor in southern China and Southeast Asia. Metastasis of NPC remains the main cause of death for NPC patients even though the tumor is sensitive to radiotherapy and chemotherapy. Here, we found that the transmembrane protein tetraspanin1 (TSPAN1) potently inhibited the in vitro migration and invasion, as well as, the in vivo metastasis of NPC cells via interacting with the IKBB protein. In addition, TSPAN1 was essential in preventing the overactivation of the NF-kB pathway in TSPAN1 overexpressing NPC cells. Furthermore, reduced TSPAN1 expression was associated with NPC metastasis and the poor prognosis of NPC patients. These results uncovered the suppressive role of TSPAN1 against NF-kB signaling in NPC cells for preventing NPC metastasis. Its therapeutic value warrants further investigation.
鼻咽癌（NPC）起源于鼻咽部的上皮细胞，是中国南方和东南亚地区常见的恶性肿瘤。尽管 NPC 对放疗和化疗敏感，但 NPC 患者的转移仍然是死亡的主要原因。在这里，我们发现跨膜蛋白四旋蛋白 1（TSPAN1）通过与 IKBB 蛋白相互作用，强烈抑制 NPC 细胞的体外迁移和侵袭，以及体内转移。此外，TSPAN1 对于防止 TSPAN1 过表达 NPC 细胞中 NF-kB 通路的过度激活是必不可少的。此外，TSPAN1 的表达减少与 NPC 的转移和 NPC 患者的不良预后相关。这些结果揭示了 TSPAN1 在 NPC 细胞中对 NF-kB 信号的抑制作用，可防止 NPC 转移。其治疗价值值得进一步研究。
