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十四酰佛波醇-13-乙酸酯和聚戊烯酸衍生物对猪皮钙激活磷脂依赖性蛋白激酶的影响。

Effects of 12-o-tetradecanoylphorbol-13-acetate and polyprenoic acid derivative on calcium-activated phospholipid-dependent protein kinase of pig skin.

作者信息

Koizumi H, Suya H, Nemoto O, Aoyagi T, Ohkawara A

出版信息

Arch Dermatol Res. 1986;279(1):50-3. doi: 10.1007/BF00404358.

DOI:10.1007/BF00404358
PMID:3813653
Abstract

12-o-Tetradecanoylphorbol-13-acetate (TPA) activates calcium-activated, phospholipid-dependent protein kinase (protein kinase C) partially purified in an ion exchange column from pig epidermis. Protein kinase C was activated by TPA in a concentration-dependent manner with simultaneous addition of Ca2+ and phospholipid. Polyprenoic acid derivative (E5166) which is a newly synthesized retinoic acid derivative, inhibited the TPA activation of protein kinase C. This inhibition may explain the mechanisms by which retinoids inhibit TPA-induced tumor promotion.

摘要

12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）可激活从猪表皮离子交换柱中部分纯化得到的钙激活的、磷脂依赖性蛋白激酶（蛋白激酶C）。在同时添加Ca2+和磷脂的情况下，TPA以浓度依赖性方式激活蛋白激酶C。新合成的视黄酸衍生物多聚烯酸衍生物（E5166）可抑制TPA对蛋白激酶C的激活。这种抑制作用可能解释了类视黄醇抑制TPA诱导的肿瘤促进作用的机制。

相似文献

1
Effects of 12-o-tetradecanoylphorbol-13-acetate and polyprenoic acid derivative on calcium-activated phospholipid-dependent protein kinase of pig skin.十四酰佛波醇-13-乙酸酯和聚戊烯酸衍生物对猪皮钙激活磷脂依赖性蛋白激酶的影响。
Arch Dermatol Res. 1986;279(1):50-3. doi: 10.1007/BF00404358.
2
[Studies of calcium-activated, phospholipid-dependent protein kinase in pig epidermis].[猪表皮中钙激活的磷脂依赖性蛋白激酶的研究]
Hokkaido Igaku Zasshi. 1986 Jul;61(4):521-32.
3
Retinoid effect on calcium, phospholipid-dependent protein kinase from mouse skin.维甲酸对小鼠皮肤中钙、磷脂依赖性蛋白激酶的作用。
J Invest Dermatol. 1986 Mar;86(3):316-20. doi: 10.1111/1523-1747.ep12285514.
4
Inhibition of tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced synthesis of epidermal ornithine decarboxylase messenger RNA and diacylglycerol-promoted mouse skin tumor formation by retinoic acid.维甲酸对肿瘤启动子12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯诱导的表皮鸟氨酸脱羧酶信使核糖核酸合成及二酰基甘油促进的小鼠皮肤肿瘤形成的抑制作用。
Cancer Res. 1988 Apr 15;48(8):2168-73.
5
Catalytic and receptor-binding properties of the calcium-sensitive phospholipid-dependent protein kinase (protein kinase C) in swine luteal cytosol.猪黄体细胞质中钙敏感磷脂依赖性蛋白激酶（蛋白激酶C）的催化及受体结合特性
Mol Cell Endocrinol. 1987 Mar;50(1-2):123-9. doi: 10.1016/0303-7207(87)90084-0.
6
Flavonoid modulation of protein kinase C activation.
Life Sci. 1989;44(21):1563-71. doi: 10.1016/0024-3205(89)90450-5.
7
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and epidermal ornithine decarboxylase activity in mouse skin by palmitoylcarnitine.棕榈酰肉碱对12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯诱导的小鼠皮肤肿瘤促进作用及表皮鸟氨酸脱羧酶活性的抑制作用。
Cancer Res. 1986 Apr;46(4 Pt 1):1589-93.
8
Bryostatin 1, an activator of protein kinase C, mimics as well as inhibits biological effects of the phorbol ester TPA in vivo and in vitro.苔藓抑素1是一种蛋白激酶C激活剂，在体内和体外既能模拟又能抑制佛波酯TPA的生物学效应。
Carcinogenesis. 1988 Apr;9(4):555-62. doi: 10.1093/carcin/9.4.555.
9
The bile acid analog fusidic acid can replace phosphatidylserine in the activation of protein kinase C by 12-O-tetradecanoylphorbol-13-acetate in vitro.胆汁酸类似物夫西地酸在体外可替代磷脂酰丝氨酸，参与由12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯激活蛋白激酶C的过程。
Carcinogenesis. 1988 Aug;9(8):1451-4. doi: 10.1093/carcin/9.8.1451.
10
Phorbol ester activation of epidermal protein kinase C from tumor promotion sensitive and resistant mouse strains.佛波酯对来自肿瘤促进敏感和抗性小鼠品系的表皮蛋白激酶C的激活作用。
Cancer Lett. 1985 Nov;29(2):215-21. doi: 10.1016/0304-3835(85)90161-2.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.二酰基甘油对钙和磷脂依赖性蛋白激酶的激活作用及其与磷脂酰肌醇代谢的可能关系。
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In vitro binding affinity of novel synthetic polyprenoids (polyprenoic acids) to cellular retinoid-binding proteins.新型合成聚萜类化合物（聚戊烯酸）对细胞类视黄醇结合蛋白的体外结合亲和力。
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Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.肿瘤促进剂佛波酯对钙激活的、磷脂依赖性蛋白激酶的直接激活作用。
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Modulation of terminal differentiation and responses to tumor promoters by retinoids in mouse epidermal cell cultures.视黄酸对小鼠表皮细胞培养中终末分化及肿瘤启动子反应的调节作用。
Ann N Y Acad Sci. 1981 Feb 27;359:260-73. doi: 10.1111/j.1749-6632.1981.tb12752.x.
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Characterization of cytosolic calcium-activated phospholipid-dependent protein kinase activity in embryonal carcinoma cells. Effect of retinoc acid-induced differentiation of F9 cells to parietal endoderm.胚胎癌细胞中胞质钙激活磷脂依赖性蛋白激酶活性的特征。视黄酸诱导F9细胞分化为壁内胚层的作用。
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Retinal inhibits TPA activated, calcium-dependent, phospholipid-dependent protein kinase ("C" kinase).视网膜抑制佛波酯激活的、钙依赖性、磷脂依赖性蛋白激酶（“C”激酶）。
Biochem Biophys Res Commun. 1983 Aug 12;114(3):1194-9. doi: 10.1016/0006-291x(83)90689-7.
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Antitumor activity of vitamin A and its derivatives.
J Natl Cancer Inst. 1984 Dec;73(6):1389-93.
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The development of retinoids in experimental and clinical oncology and dermatology.维甲酸在实验性和临床肿瘤学及皮肤病学中的发展。
J Am Acad Dermatol. 1983 Nov;9(5):797-805. doi: 10.1016/s0190-9622(83)80143-1.
10
Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.蛋白激酶C作为促肿瘤佛波酯的一种可能的受体蛋白。
J Biol Chem. 1983 Oct 10;258(19):11442-5.