Cummine Jacqueline, Ngo Tiffany, Nisbet Kelly
Department of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB T6G2G4, Canada.
Neuroscience and Mental Health Institute, Faculty of Medicine, University of Alberta, Edmonton, AB T6G2G4, Canada.
Brain Sci. 2023 Nov 23;13(12):1622. doi: 10.3390/brainsci13121622.
Multiple cortical (planum temporale, supramarginal gyrus, fusiform gyrus) and subcortical (caudate, putamen, and thalamus) regions have shown different functional lateralization patterns for skilled vs. dyslexic readers. The extent to which skilled and dyslexic adult readers show differential structural lateralization remains to be seen. Method: Participants included 72 adults (N = 41 skilled; N = 31 dyslexic) who underwent a high-resolution MRI brain scan. The grey matter volume of the cortical and subcortical structures was extracted. Results: While there were clear behavioral differences between the groups, there were no differences in any of the isolated structures (i.e., either total size or asymmetry index) and limited evidence for any brain-behavior relationships. We did find a significant cortical-cortical relationship ( = 0.006) and a subcortical-subcortical relationship ( = 0.008), but not cross-over relationships. Overall, this work provides unique information on neural structures as they relate to reading in skilled and dyslexic readers.
多个皮质区域（颞平面、缘上回、梭状回）和皮质下区域（尾状核、壳核和丘脑）在熟练阅读者与阅读障碍者中呈现出不同的功能偏侧化模式。成年熟练阅读者和阅读障碍者在结构偏侧化方面的差异程度仍有待观察。方法：参与者包括72名成年人（N = 41名熟练阅读者；N = 31名阅读障碍者），他们接受了高分辨率MRI脑部扫描。提取了皮质和皮质下结构的灰质体积。结果：虽然两组之间存在明显的行为差异，但在任何孤立结构（即总体大小或不对称指数）上均无差异，且几乎没有证据表明存在任何脑-行为关系。我们确实发现了显著的皮质-皮质关系（= 0.006）和皮质下-皮质下关系（= 0.008），但没有交叉关系。总体而言，这项研究提供了与熟练阅读者和阅读障碍者阅读相关的神经结构的独特信息。
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