阿片肽系统对心肌梗死后患者传导障碍的影响。

Influence of the Apelinergic System on Conduction Disorders in Patients after Myocardial Infarction.

作者信息

Wyderka Rafał, Diakowska Dorota, Łoboz-Rudnicka Maria, Mercik Jakub, Borger Michał, Osuch Łukasz, Brzezińska Barbara, Leśków Anna, Krzystek-Korpacka Małgorzata, Jaroch Joanna

机构信息

Department of Cardiology, Tadeusz Marciniak Lower Silesia Specialist Hospital-Emergency Medicine Center, Fieldorf 2, 54-049 Wroclaw, Poland.

Faculty of Medicine, Wrocław University of Science and Technology, 50-370 Wroclaw, Poland.

出版信息

J Clin Med. 2023 Dec 10;12(24):7603. doi: 10.3390/jcm12247603.

DOI:10.3390/jcm12247603

PMID:38137673

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10744328/

Abstract

BACKGROUND

There is a growing body of evidence for an important role of the apelinergic system in the modulation of cardiovascular homeostasis. The aim of our study was to (1) examine the relationship between apelin serum concentration at index myocardial infarction (MI) and atrioventricular conduction disorders (AVCDs) at 12-month follow-up, and (2) investigate the association between initial apelin concentration and the novel marker of post-MI scar (Q/QRS ratio) at follow-up.

METHODS

In 84 patients with MI with complete revascularization, apelin peptide serum concentrations for apelin-13, apelin-17, elabela (ELA) and apelin receptor (APJ) were measured on day one of hospitalization; at 12-month follow-up, 54 of them underwent thorough examination that included 12-lead electrocardiography (ECG), Holter ECG monitoring and echocardiography.

RESULTS

The mean age was 58.9 years. At 12-month follow-up, AVCDs were diagnosed in 21.4% of subjects, with AV first-degree block in 16.7% and sinoatrial arrest in 3.7%. ELA serum concentration at index MI correlated positively with the occurrence of AVCD ( = 0.003) and heart rate ( = 0.005) at 12-month follow-up. The apelin-13 serum concentration at index MI correlated negatively with the Q/QRS ratio.

CONCLUSIONS

The apelin peptide concentration during an acute phase of MI impacts the development of AVCD and the value of Q/QRS ratio in MI survivors.

摘要

背景

越来越多的证据表明阿片肽系统在调节心血管稳态中起重要作用。我们研究的目的是：（1）检查首次心肌梗死（MI）时阿片肽血清浓度与12个月随访时房室传导障碍（AVCDs）之间的关系；（2）研究初始阿片肽浓度与随访时MI后瘢痕新标志物（Q/QRS比值）之间的关联。

方法

在84例完全血运重建的MI患者中，于住院第一天测量阿片肽-13、阿片肽-17、艾拉芬肽（ELA）和阿片肽受体（APJ）的阿片肽血清浓度；在12个月随访时，其中54例患者接受了全面检查，包括12导联心电图（ECG）、动态心电图监测和超声心动图检查。

结果

平均年龄为58.9岁。在12个月随访时，21.4%的受试者被诊断为AVCDs，其中一度房室传导阻滞占16.7%，窦性停搏占3.7%。首次MI时ELA血清浓度与12个月随访时AVCD的发生（P = 0.003）和心率（P = 0.005）呈正相关。首次MI时阿片肽-13血清浓度与Q/QRS比值呈负相关。