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杆菌肽，一种杀菌抗生素，也是一种卵巢癌细胞的抗增殖剂。

Gramicidin, a Bactericidal Antibiotic, Is an Antiproliferative Agent for Ovarian Cancer Cells.

机构信息

Department of Biopharmaceutical Chemistry, Kookmin University, Seoul 02707, Republic of Korea.

Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, Republic of Korea.

出版信息

Medicina (Kaunas). 2023 Nov 22;59(12):2059. doi: 10.3390/medicina59122059.

DOI:10.3390/medicina59122059
PMID:38138162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10744341/
Abstract

: Gramicidin, a bactericidal antibiotic used in dermatology and ophthalmology, has recently garnered attention for its inhibitory actions against cancer cell growth. However, the effects of gramicidin on ovarian cancer cells and the underlying mechanisms are still poorly understood. We aimed to elucidate the anticancer efficacy of gramicidin against ovarian cancer cells. : The anticancer effect of gramicidin was investigated through an in vitro experiment. We analyzed cell proliferation, DNA fragmentation, cell cycle arrest and apoptosis in ovarian cancer cells using WST-1 assay, terminal deoxynucleotidyl transferase dUTP nick and labeling (TUNEL), DNA agarose gel electrophoresis, flow cytometry and western blot. : Gramicidin treatment induces dose- and time-dependent decreases in OVCAR8, SKOV3, and A2780 ovarian cancer cell proliferation. TUNEL assay and DNA agarose gel electrophoresis showed that gramicidin caused DNA fragmentation in ovarian cancer cells. Flow cytometry demonstrated that gramicidin induced cell cycle arrest. Furthermore, we confirmed via Western blot that gramicidin triggered apoptosis in ovarian cancer cells. : Our results strongly suggest that gramicidin exerts its inhibitory effect on cancer cell growth by triggering apoptosis. Conclusively, this study provides new insights into the previously unexplored anticancer properties of gramicidin against ovarian cancer cells.

摘要

: 黏菌素是一种在皮肤科和眼科中使用的杀菌抗生素，最近因其抑制癌细胞生长的作用而受到关注。然而，黏菌素对卵巢癌细胞的作用及其潜在机制仍知之甚少。我们旨在阐明黏菌素对卵巢癌细胞的抗癌功效。: 本研究通过体外实验探讨了黏菌素的抗癌作用。我们使用 WST-1 测定法、末端脱氧核苷酸转移酶 dUTP 缺口末端标记（TUNEL）、DNA 琼脂糖凝胶电泳、流式细胞术和 Western blot 分析了黏菌素对卵巢癌细胞增殖、DNA 片段化、细胞周期停滞和凋亡的影响。: 黏菌素处理诱导 OVCAR8、SKOV3 和 A2780 卵巢癌细胞增殖呈剂量和时间依赖性下降。TUNEL 分析和 DNA 琼脂糖凝胶电泳显示黏菌素引起卵巢癌细胞 DNA 片段化。流式细胞术表明黏菌素诱导细胞周期停滞。此外，我们通过 Western blot 证实黏菌素诱导卵巢癌细胞凋亡。: 我们的结果强烈表明，黏菌素通过触发细胞凋亡来发挥其抑制癌细胞生长的作用。总之，本研究为黏菌素对卵巢癌细胞的抗癌特性提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1eb/10744341/4c88027e208e/medicina-59-02059-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1eb/10744341/4da3f61bd521/medicina-59-02059-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1eb/10744341/4077a10c69d3/medicina-59-02059-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1eb/10744341/d2f86a380d94/medicina-59-02059-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1eb/10744341/4c88027e208e/medicina-59-02059-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1eb/10744341/4da3f61bd521/medicina-59-02059-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1eb/10744341/4077a10c69d3/medicina-59-02059-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1eb/10744341/d2f86a380d94/medicina-59-02059-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1eb/10744341/4c88027e208e/medicina-59-02059-g004.jpg

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