Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania.
Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania.
Medicina (Kaunas). 2023 Dec 17;59(12):2191. doi: 10.3390/medicina59122191.
Hepatocellular carcinoma (HCC) still lacks valuable diagnostic and prognostic tools. This study aimed to investigate the potential diagnostic and prognostic value of baseline interleukin (IL)-10, fatty acid-binding protein 2 (FABP2) and lipopolysaccharide (LPS) levels in patients with HCC. Serum levels of IL-10, FABP2 and LPS in 47 newly diagnosed HCC patients and 50 healthy individuals were estimated and compared. The best cut-off points for baseline IL-10, FABP2 and LPS levels predicting overall survival (OS) were evaluated. Both levels of FABP2 and IL-10 were significantly higher in HCC patients vs. control group (median 2095 vs. 1772 pg/mL, = 0.026; 9.94 vs. 4.89 pg/mL, < 0.001) and may serve as potential biomarkers in complex HCC diagnostic tools. The cut-off value of 2479 pg/mL for FABP2 was determined to have the highest sensitivity (66.7%) and specificity (55.6%) to distinguish patients with a median OS longer than 17 months. However, the median OS of patients with high and low levels of FABP2 were not significantly different ( = 0.896). The prognostic value of LPS as well as FABP2 and IL-10 for HCC patients appears to be limited.
肝细胞癌 (HCC) 仍然缺乏有价值的诊断和预后工具。本研究旨在探讨基线白细胞介素 (IL)-10、脂肪酸结合蛋白 2 (FABP2) 和脂多糖 (LPS) 水平在 HCC 患者中的潜在诊断和预后价值。评估了 47 例新诊断 HCC 患者和 50 例健康个体的血清 IL-10、FABP2 和 LPS 水平，并进行了比较。评估了基线 IL-10、FABP2 和 LPS 水平预测总生存期 (OS) 的最佳截断值。与对照组相比，FABP2 和 IL-10 水平在 HCC 患者中均显著升高（中位数 2095 与 1772 pg/mL， = 0.026；9.94 与 4.89 pg/mL， < 0.001），并且可能作为复杂 HCC 诊断工具中的潜在生物标志物。确定 FABP2 的截断值为 2479 pg/mL 时，具有区分中位 OS 超过 17 个月患者的最高敏感性（66.7%）和特异性（55.6%）。然而，FABP2 水平高和低的患者的中位 OS 无显著差异（ = 0.896）。LPS 以及 FABP2 和 IL-10 对 HCC 患者的预后价值似乎有限。
