Brown C, Gross W B, Ehrich M
Avian Dis. 1986 Oct-Dec;30(4):679-82.
Thirty-eight 7-week-old white leghorn chickens of two strains (high and low antibody response to sheep erythrocytes) were divided into groups for exposure to high and low levels of social stress. They were then challenged orally with a toxic dose of the organophosphate insecticide malathion (250 mg/kg body weight) and evaluated 60 min later for muscarinic signs (diarrhea, lacrimation, respiratory secretions), nicotinic signs (muscle weakness), plasma cholinesterase activity, and brain acetylcholinesterase activity. A significant correlation was shown between clinical and biochemical indices of organophosphate toxicity. The correlation between social stress and malathion toxicity was less well defined. Chickens with low antibody response preexposed to high social stress were most resistant to organophosphate toxicity.
38只7周龄的两个品系（对绵羊红细胞抗体反应高和低）的白来航鸡被分成几组，分别暴露于高和低水平的社会应激。然后给它们口服致死剂量的有机磷杀虫剂马拉硫磷（250毫克/千克体重），60分钟后评估其毒蕈碱样症状（腹泻、流泪、呼吸道分泌物）、烟碱样症状（肌肉无力）、血浆胆碱酯酶活性和脑乙酰胆碱酯酶活性。有机磷中毒的临床和生化指标之间显示出显著相关性。社会应激与马拉硫磷毒性之间的相关性不太明确。预先暴露于高社会应激的抗体反应低的鸡对有机磷毒性最具抵抗力。
