Nowack H, Eckenberger H P
Arzneimittelforschung. 1986 Oct;36(10):1550-2.
Ten patients who were scheduled for surgery due to an internal damage of the knee joint, were treated 2 days before operation 3 times daily with an ointment containing flufenamic acid (Mobilisin spezial). At the time of operation, plasma and synovial fluid, tissue samples from the synovial membrane, Hoffa's fat pad and-- as far as possible--meniscus and articular cartilage were taken. Until 72 h after the operation, urine samples were collected. The flufenamic acid level was determined by means of high pressure liquid chromatography associated with fluorometric detection. Flufenamic acid was detected in all tissues of the knee joint and in the synovial fluid. The highest concentration of flufenamic acid was found in the synovial membrane.
十名因膝关节内部损伤而计划接受手术的患者，在手术前2天每天接受3次含有氟芬那酸（Mobilisin spezial）的药膏治疗。手术时，采集了血浆、滑液、滑膜组织样本、霍法脂肪垫样本，以及尽可能采集的半月板和关节软骨样本。术后72小时内收集尿液样本。通过与荧光检测相关联的高压液相色谱法测定氟芬那酸水平。在膝关节的所有组织和滑液中均检测到氟芬那酸。滑膜中氟芬那酸的浓度最高。
