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菠萝蜜成分在人类疾病防控中的功效:一项范围综述。

Efficacy of jackfruit components in prevention and control of human disease: A scoping review.

作者信息

Tripathi Kanchan, Kumar Prashant, Kumar Rahul, Saxena Rahul, Kumar Ankur, Badoni Himani, Goyal Bela, Mirza Anissa Atif

机构信息

Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

School of Applied Life Sciences, Uttranchal University, Dehradun, Uttarakhand, India.

出版信息

J Educ Health Promot. 2023 Oct 31;12:361. doi: 10.4103/jehp.jehp_1683_22. eCollection 2023.

Abstract

The jackfruit () is one of the natural remedies significantly used in folk medicine. The ethnopharmacological applications of jackfruit are mainly concerned with the management of inflammation, diarrhea, and diabetes mellitus. Flavonoids, stilbenoids, aryl benzofurans, and lectin jacalin are abundant in jackfruit species. Jacalin is a good indicator for evaluating the immunological state of HIV-1 patients. The extracts and metabolites of jackfruit, particularly those from the leaves, bark, stem, and fruit, contain several beneficial bioactive mixtures. New studies are focused on exploring these bioactive compounds used in various biological activities such as antiviral, antiplatelet, anticancer, antiatherosclerotic, immunomodulatory effects, inhibitors of 5-alpha reductase activity, and the formulation of fast-dissolving tablets (orodispersible, rapid melts porous). Multidisciplinary programs that integrate traditional and modern technology play a crucial role in the lies ahead expansion of jackfruit as the prospective inception of therapeutic compounds. This review aims to highlight significant results on the identification, production, and bioactivity of metabolites found in jackfruit, with current developments in jackfruit research in the control and prevention of human diseases.

摘要

波罗蜜()是民间医学中大量使用的天然药物之一。波罗蜜的民族药理学应用主要涉及炎症、腹泻和糖尿病的治疗。波罗蜜属植物富含黄酮类化合物、芪类化合物、芳基苯并呋喃和凝集素菠萝素。菠萝素是评估HIV-1患者免疫状态的良好指标。波罗蜜的提取物和代谢产物,特别是来自叶、树皮、茎和果实的提取物和代谢产物,含有几种有益的生物活性混合物。新的研究集中在探索这些用于各种生物活性的生物活性化合物,如抗病毒、抗血小板、抗癌、抗动脉粥样硬化、免疫调节作用、5-α还原酶活性抑制剂以及速溶片(口腔崩解片、速溶多孔片)的配方。整合传统技术和现代技术的多学科项目在波罗蜜作为治疗化合物的潜在起始物的未来扩展中起着至关重要的作用。本综述旨在强调波罗蜜中发现的代谢产物的鉴定、生产和生物活性的重要结果,以及波罗蜜在人类疾病控制和预防研究中的当前进展。

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