Li Kang, Geng Yanpei, Lin Bencheng, Xi Zhuge
Department of Health Toxicology, Tianjin Institute of Environmental and Operational Medicine, Tianjin 300050, China.
Toxicol Res (Camb). 2023 Oct 19;12(6):1014-1023. doi: 10.1093/toxres/tfad094. eCollection 2023 Dec.
Mitochondria and endoplasmic reticulum (ER) are essential organelles playing pivotal roles in the regulation of cellular metabolism, energy production, and protein synthesis. In addition, these organelles are important targets susceptible to external stimuli, such as environmental pollutants. Exposure to environmental pollutants can cause the mitochondrial damage, endoplasmic reticulum stress (ERS), and oxidative stress, leading to cellular dysfunction and death. Therefore, understanding the toxic effects and molecular mechanisms of environmental pollution underlying these processes is crucial for developing effective strategies to mitigate the adverse effects of environmental pollutants on human health. In the present study, we summarized and reviewed the toxic effects and molecular mechanisms of mitochondrial damage, ERS, and oxidative stress caused by exposure to environmental pollutants as well as interactions inducing the cell apoptosis and the roles in exposure to environmental pollutants.
线粒体和内质网（ER）是重要的细胞器，在细胞代谢、能量产生和蛋白质合成的调节中发挥着关键作用。此外，这些细胞器是易受外部刺激（如环境污染物）影响的重要靶点。接触环境污染物可导致线粒体损伤、内质网应激（ERS）和氧化应激，进而导致细胞功能障碍和死亡。因此，了解这些过程背后的环境污染毒性效应和分子机制，对于制定有效策略减轻环境污染物对人类健康的不利影响至关重要。在本研究中，我们总结并综述了接触环境污染物所导致的线粒体损伤、ERS和氧化应激的毒性效应及分子机制，以及诱导细胞凋亡的相互作用和在接触环境污染物中的作用。
