Luedemann R E, Thomas K A, Cook S D
Biomater Med Devices Artif Organs. 1986;14(3-4):181-94. doi: 10.3109/10731198609117542.
The tissue response and bone remodeling associated with a flexible femoral intramedullary implant was evaluated. The implant consisted of wafers of porous Co-Cr-Mo alloy and microporous LTI pyrolytic carbon. Six wafers of each material were assembled in a stack and held together using a central acrylic rod. Radiography and histology demonstrated that these implants were associated with gross bone remodeling changes in the femoral shaft. The bone remodeling consisted of endosteal surface bone resorption and periosteal surface bone deposition, most likely due to a loss of structural support from the reamed medullary canal. The periosteal surface bone deposition resulted in an increase in femoral shaft diameter of 5% - 140%. The bone-implant interface consisted of a fibrous connective tissue with limited areas of bone ingrowth or bone apposition.
评估了与柔性股骨髓内植入物相关的组织反应和骨重塑。该植入物由多孔钴铬钼合金薄片和微孔低温各向同性热解碳组成。每种材料的六个薄片堆叠在一起，并用中心丙烯酸棒固定在一起。放射学和组织学表明，这些植入物与股骨干的明显骨重塑变化有关。骨重塑包括骨内膜表面骨吸收和骨膜表面骨沉积，这很可能是由于扩髓髓腔的结构支撑丧失所致。骨膜表面骨沉积导致股骨干直径增加5% - 140%。骨-植入物界面由纤维结缔组织组成，骨长入或骨附着区域有限。
