Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350116, China.
Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350116, China.
J Hazard Mater. 2024 Mar 5;465:133246. doi: 10.1016/j.jhazmat.2023.133246. Epub 2023 Dec 14.
The exposure of micro- and nanoplastics (MNPs) via medical device is still unknown to us. Herein, a visual quantitative detection of polyvinyl chloride (PVC) MPs and a fluorescent quantitative detection of PVC NPs were developed. To overcome the aggregation of PVC NPs, sodium dodecylbenzene sulfonate was used as the stabilizer of PVC NPs. The brand-new disposable PVC infusion tubes were found to carry PVC MPs with the average total number (ATN) of 931.4 particles and PVC NPs with the average mass of 0.040 μg, respectively. For four typical infusion fluids such as 0.9% sodium chloride, 5% glucose, 5% sodium bicarbonate, hydroxyethyl starch 40 sodium chloride, the released PVC MPs and NPs were ranged from 1003.6 ∼ 3494.6 particles and 0.042 ∼ 0.087 μg, respectively in stimulating normal infusion scenario (room temperature 4 h). The released PVC MPs and NPs were also increased with the infusion duration and temperature. The released PVC MPs are mainly in granular form, accounting for 38 ∼ 49% of the total PVC MPs. Our findings indicate PVC MNPs can enter the blood vessel directly with the infusion fluids during intravenous infusion and the PVC MNPs exposure risk towards patients deserves more attention.
我们目前还不清楚医疗器械中微塑料和纳米塑料（MNPs）的暴露情况。在此，我们开发了一种用于定量检测聚氯乙烯（PVC） MPs 的可视化方法和一种用于定量检测 PVC NPs 的荧光方法。为了克服 PVC NPs 的聚集问题，我们使用十二烷基苯磺酸钠作为 PVC NPs 的稳定剂。全新的一次性 PVC 输液管中被发现携带 PVC MPs，其总数（ATN）为 931.4 个颗粒，PVC NPs 的平均质量为 0.040μg。对于四种典型的输液，如 0.9%氯化钠、5%葡萄糖、5%碳酸氢钠和羟乙基淀粉 40 氯化钠，在刺激正常输液场景（室温 4 小时）下，释放的 PVC MPs 和 NPs 的范围分别为 1003.6∼3494.6 个颗粒和 0.042∼0.087μg。释放的 PVC MPs 和 NPs 也随着输液时间和温度的增加而增加。释放的 PVC MPs 主要以颗粒形式存在，占总 PVC MPs 的 38∼49%。我们的研究结果表明，在静脉输液过程中，PVC MNPs 可以随输液直接进入血管，患者面临的 PVC MNPs 暴露风险值得进一步关注。
