Gubriĭ I B, Reznikov A G, Demchenko V N, Butenko G M
Biull Eksp Biol Med. 1987 Feb;103(2):205-8.
Female mice 3 and 22-24 months of age were jointed in heterochronic parabiosis. That led to permanent estrus in young mice and maintenance of intact anestrus in old mice. After 8-9 weeks of parabiosis there appeared morphological signs of accelerated ageing in the ovaries of young animals, while no changes in the ovaries of old mice were observed. Serum progesterone of young partners decreased to the levels of old animals and estradiol levels remained unchanged, while prolactin content in adenohypophysis was the same as in young single animals but exceeded the level noted in young mice in parabiosis with young partners. Hormone content in old parabionts remained unchanged, as compared to the control. An old organism is thought to be the source of unidentified factors suppressing the ovarian function in young animals.
将3月龄和22 - 24月龄的雌性小鼠进行异时联体共生。这导致年轻小鼠永久性发情，而老年小鼠维持完整的静止期。联体共生8 - 9周后，年轻动物卵巢出现加速衰老的形态学迹象，而老年小鼠卵巢未观察到变化。年轻联体伙伴的血清孕酮降至老年动物水平，雌二醇水平保持不变，而腺垂体中的催乳素含量与年轻单只动物相同，但超过了与年轻伙伴联体共生的年轻小鼠中的水平。与对照组相比，老年联体动物的激素含量保持不变。老年生物体被认为是抑制年轻动物卵巢功能的未知因子的来源。
