Belianin V L, Kerimov A Kh
Biull Eksp Biol Med. 1987 Feb;103(2):224-6.
Intratracheal challenge of rabbits and intranasal challenge of white mice and guinea-pigs by C. albicans without the application of adhesive substances, produced candidiasis pneumonia running more severe course in mice than in rabbits. In guinea-pigs the disease was of medium severity. Specific features of pulmonary inflammation in rabbits were marked polynuclear and especially macrophage reactions, with the phagocyte activity high enough to ensure total elimination of pathogenic microorganisms in the animal. In white mice a weak macrophage reaction was actually a background for a predominant polynuclear reaction producing a massive polynuclear leukocyte disintegration. These processes, though eliminating pathogenic organisms both by phagocytosis and non-phagocytic mechanisms, lead to severe fatal pulmonary edema. Specific differences in experimental lung candidiasis reveal various manifestation of human lung candidiasis.
在不使用黏附物质的情况下，用白色念珠菌对家兔进行气管内攻击，对小白鼠和豚鼠进行鼻内攻击，结果显示，小白鼠发生的念珠菌性肺炎病程比家兔更严重。豚鼠所患疾病为中等严重程度。家兔肺部炎症的特征是明显的多核细胞反应，尤其是巨噬细胞反应，吞噬细胞活性足以确保动物体内致病微生物被完全清除。在小白鼠中，微弱的巨噬细胞反应实际上是占主导的多核细胞反应的背景，该反应导致大量多核白细胞解体。这些过程虽然通过吞噬作用和非吞噬机制清除了致病生物，但会导致严重的致命性肺水肿。实验性肺部念珠菌病的具体差异揭示了人类肺部念珠菌病的各种表现形式。
